User profiles for J. M. Carthy
Jon CarthyResearch Associate, Imperial College London Verified email at imperial.ac.uk Cited by 1051 |
TGFβ signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders
JM Carthy - Journal of cellular physiology, 2018 - Wiley Online Library
The myofibroblast is a highly specialized cell type that plays a critical role during normal
tissue wound healing, but also contributes pathologically to chronic inflammatory conditions …
tissue wound healing, but also contributes pathologically to chronic inflammatory conditions …
Versican: signaling to transcriptional control pathways
Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular
matrix, which provides a loose and hydrated matrix during key events in development …
matrix, which provides a loose and hydrated matrix during key events in development …
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
GS Ralph, PA Radcliffe, DM Day, JM Carthy… - Nature medicine, 2005 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease resulting in the
selective death of motor neurons in the brain and spinal cord 1 . Some familial cases of ALS are …
selective death of motor neurons in the brain and spinal cord 1 . Some familial cases of ALS are …
[HTML][HTML] Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner
JM Carthy, FS Garmaroudi, Z Luo, BM McManus - PloS one, 2011 - journals.plos.org
Growing evidence suggests the Wnt family of secreted glycoproteins and their associated
signaling pathways, linked to development, are recapitulated during wound repair and …
signaling pathways, linked to development, are recapitulated during wound repair and …
[HTML][HTML] Coffee and tomato share common gene repertoires as revealed by deep sequencing of seed and cherry transcripts
C Lin, LA Mueller, JM Carthy, D Crouzillat… - Theoretical and applied …, 2005 - Springer
An EST database has been generated for coffee based on sequences from approximately
47,000 cDNA clones derived from five different stages/tissues, with a special focus on …
47,000 cDNA clones derived from five different stages/tissues, with a special focus on …
Tamoxifen inhibits TGF‐β‐mediated activation of myofibroblasts by blocking non‐Smad signaling through ERK1/2
JM Carthy, A Sundqvist, A Heldin… - Journal of cellular …, 2015 - Wiley Online Library
Transforming growth factor‐β (TGF‐β) is a multifunctional cytokine which stimulates the
differentiation of fibroblasts into myofibroblasts. Myofibroblasts are critical for normal wound …
differentiation of fibroblasts into myofibroblasts. Myofibroblasts are critical for normal wound …
[HTML][HTML] Regulation of the versican promoter by the β-catenin-T-cell factor complex in vascular smooth muscle cells
M Rahmani, JT Read, JM Carthy, PC McDonald… - Journal of Biological …, 2005 - ASBMB
The proteoglycan versican is pro-atherogenic and central to vascular injury and repair
events. We identified the signaling pathways and promoter elements involved in regulation of …
events. We identified the signaling pathways and promoter elements involved in regulation of …
[HTML][HTML] Versican V1 overexpression induces a myofibroblast-like phenotype in cultured fibroblasts
Background Versican, a chondroitin sulphate proteoglycan, is one of the key components of
the provisional extracellular matrix expressed after injury. The current study evaluated the …
the provisional extracellular matrix expressed after injury. The current study evaluated the …
In vitro and ex vivo vanadium antitumor activity in (TGF-β)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients
…, K Domvri, P Zarogoulidis, JM Carthy… - … International Journal of …, 2016 - Elsevier
Epithelial to mesenchymal transition (EMT) plays a key role in tumor progression and metastasis
as a crucial event for cancer cells to trigger the metastatic niche. Transforming growth …
as a crucial event for cancer cells to trigger the metastatic niche. Transforming growth …
Taurolidine, an antilipopolysaccharide agent, has immunoregulatory properties that are mediated by the amino acid taurine
…, G Watson, HP Redmond, JM Carthy… - Journal of leukocyte …, 1995 - Wiley Online Library
Taurolidine has bactericidal and antilipopolysaccharide properties. It is broken down into
the amino acid taurine, which has been shown to modulate intracellular calcium activity, a …
the amino acid taurine, which has been shown to modulate intracellular calcium activity, a …