Insights into recent findings and clinical application of YAP and TAZ in cancer
Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif …
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif …
Evaluating the use of nonrandomized real‐world data analyses for regulatory decision making
JM Franklin, RJ Glynn, D Martin… - Clinical Pharmacology …, 2019 - Wiley Online Library
The analysis of longitudinal healthcare data outside of highly controlled parallel‐group
randomized trials, termed real‐world evidence ( RWE ), has received increasing attention in the …
randomized trials, termed real‐world evidence ( RWE ), has received increasing attention in the …
Two decades of new drug development for central nervous system disorders
AS Kesselheim, TJ Hwang, JM Franklin - Nature Reviews. Drug …, 2015 - nature.com
The social, clinical and economic need for improved therapies for central nervous system (CNS)
disorders and concern about the lack of new drugs have led some groups to propose …
disorders and concern about the lack of new drugs have led some groups to propose …
Volcanic-associated massive sulfide deposits
JM Franklin, JW Lydon, DF Sangster - 1981 - pubs.geoscienceworld.org
… JM Franklin JM Franklin … JM Franklin, JW Lydon, DF Sangster, 1981. "Volcanic-Associated
Massive Sulfide Deposits", Seventy-Fifth Anniversary Volume, Brian J. Skinner …
Massive Sulfide Deposits", Seventy-Fifth Anniversary Volume, Brian J. Skinner …
Volcanogenic massive sulfide deposits
JM Franklin, HL Gibson, IR Jonasson, AG Galley - 2005 - pubs.geoscienceworld.org
… The classification system of Franklin et al. (1981), based on reported copper, lead, and
zinc contents, although quantitative and easy to use, neither describes the deposits and their …
zinc contents, although quantitative and easy to use, neither describes the deposits and their …
[HTML][HTML] ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutions
…, AG Kikhney, NR Hajizadeh, JM Franklin… - Journal of applied …, 2017 - scripts.iucr.org
ATSAS is a comprehensive software suite for the analysis of small-angle scattering data from
dilute solutions of biological macromolecules or nanoparticles. It contains applications for …
dilute solutions of biological macromolecules or nanoparticles. It contains applications for …
Emulation of randomized clinical trials with nonrandomized database analyses: results of 32 clinical trials
Importance Nonrandomized studies using insurance claims databases can be analyzed to
produce real-world evidence on the effectiveness of medical products. Given the lack of …
produce real-world evidence on the effectiveness of medical products. Given the lack of …
[HTML][HTML] Antidepressant use in pregnancy and the risk of cardiac defects
…, LS Cohen, LB Holmes, JM Franklin… - … England Journal of …, 2014 - Mass Medical Soc
Background Whether the use of selective serotonin-reuptake inhibitors (SSRIs) and other
antidepressants during pregnancy is associated with an increased risk of congenital cardiac …
antidepressants during pregnancy is associated with an increased risk of congenital cardiac …
Alternative approaches for confounding adjustment in observational studies using weighting based on the propensity score: a primer for practitioners
RJ Desai, JM Franklin - bmj, 2019 - bmj.com
This report aims to provide methodological guidance to help practitioners select the most
appropriate weighting method based on propensity scores for their analysis out of many …
appropriate weighting method based on propensity scores for their analysis out of many …
Failure of investigational drugs in late-stage clinical development and publication of trial results
…, JC Lauffenburger, B Wang, JM Franklin… - JAMA internal …, 2016 - jamanetwork.com
Importance Many investigational drugs fail in late-stage clinical development. A better
understanding of why investigational drugs fail can inform clinical practice, regulatory decisions, …
understanding of why investigational drugs fail can inform clinical practice, regulatory decisions, …