Background Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, …

Abstract Analysis of molecular aberrations across multiple cancer types, known as pan-cancer
analysis, identifies commonalities and differences in key biological processes that are …

The majority of patients with neuroblastoma have tumors that initially respond to chemotherapy,
but a large proportion will experience therapy-resistant relapses. The molecular basis of …

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we …

Neuroblastoma is a paediatric malignancy that typically arises in early childhood, and is
derived from the developing sympathetic nervous system. Clinical phenotypes range from …

Mixed phenotype acute leukaemia (MPAL) is a high-risk subtype of leukaemia with myeloid
and lymphoid features, limited genetic characterization, and a lack of consensus regarding …

The genomic and clinical information used to develop and implement therapeutic approaches
for acute myelogenous leukemia (AML) originated primarily from adult patients and has …

… Guidry Auvil; … Guidry Auvil … Guidry Auvil, Daoud Meerzaman, Qing-Rong Chen, Chih Hao
Hsu, Chunhua Yan, Cu Nguyen, Ying Hu, Yussanne Ma, Zusheng Zong, Andrew J. Mungall, …

Wilms tumour is an embryonal tumour of childhood that closely resembles the developing
kidney. Genomic changes responsible for the development of the majority of Wilms tumours …

Data-driven basic, translational, and clinical research has resulted in improved outcomes
for children, adolescents, and young adults (AYAs) with pediatric cancers. However, …