A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer
HH Workel, JM Lubbers, R Arnold, TM Prins… - Cancer immunology …, 2019 - AACR
… HH Workel and JM Lubbers are the co-first authors of this article. … Writing, review, and/or
revision of the manuscript: HH Workel, JM Lubbers, R. Arnold, P. van der Vlies, T. …
revision of the manuscript: HH Workel, JM Lubbers, R. Arnold, P. van der Vlies, T. …
A comparison between the homocyclic aromatic metabolic pathways from plant-derived compounds by bacteria and fungi
Aromatic compounds derived from lignin are of great interest for renewable biotechnical
applications. They can serve in many industries eg as biochemical building blocks for …
applications. They can serve in many industries eg as biochemical building blocks for …
[HTML][HTML] Expression of CD39 identifies activated intratumoral CD8+ T cells in mismatch repair deficient endometrial cancer
JM Lubbers, MA Ważyńska, N van Rooij, A Kol… - Cancers, 2022 - mdpi.com
Simple Summary Identification of human cancer-reactive CD8+ T cells is crucial for the
stratification of patients for immunotherapy and determination of immune-therapeutic effects. Here…
stratification of patients for immunotherapy and determination of immune-therapeutic effects. Here…
Combined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancer
A Kol, JM Lubbers, ALJ Terwindt, HH Workel… - …, 2021 - Taylor & Francis
Activation of STimulator of INterferon Genes (STING) is important for induction of anti-tumor
immunity. A dysfunctional STING pathway is observed in multiple cancer types and …
immunity. A dysfunctional STING pathway is observed in multiple cancer types and …
[HTML][HTML] A comparative genomics study of 23 Aspergillus species from section Flavi
…, ME Kogle, A Wiebenga, RS Kun, RJM Lubbers… - Nature …, 2020 - nature.com
Section Flavi encompasses both harmful and beneficial Aspergillus species, such as Aspergillus
oryzae, used in food fermentation and enzyme production, and Aspergillus flavus, food …
oryzae, used in food fermentation and enzyme production, and Aspergillus flavus, food …
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent …
…, FL Komdeur, FA Eggink, JM Lubbers… - …, 2020 - Taylor & Francis
Epithelial Ovarian cancer (EOC) is the most lethal gynecological malignancy and has limited
curative therapeutic options. Immunotherapy for EOC is promising, but clinical efficacy …
curative therapeutic options. Immunotherapy for EOC is promising, but clinical efficacy …
Association of homozygous variants of STING1 with outcome in human cervical cancer
JM Lubbers, B Koopman, JM de Klerk‐Sluis… - Cancer …, 2021 - Wiley Online Library
DNA‐sensing receptor Cyclic GMP–AMP Synthase (cGAS) and its downstream signaling
effector STimulator of INterferon Genes (STING) have gained significant interest in the field of …
effector STimulator of INterferon Genes (STING) have gained significant interest in the field of …
[HTML][HTML] Combinatorial control of gene expression in Aspergillus niger grown on sugar beet pectin
JE Kowalczyk, RJM Lubbers, M Peng, E Battaglia… - Scientific reports, 2017 - nature.com
Aspergillus niger produces an arsenal of extracellular enzymes that allow synergistic
degradation of plant biomass found in its environment. Pectin is a heteropolymer abundantly …
degradation of plant biomass found in its environment. Pectin is a heteropolymer abundantly …
[HTML][HTML] Vanillic acid and methoxyhydroquinone production from guaiacyl units and related aromatic compounds using Aspergillus niger cell factories
Background The aromatic compounds vanillin and vanillic acid are important fragrances
used in the food, beverage, cosmetic and pharmaceutical industries. Currently, most aromatic …
used in the food, beverage, cosmetic and pharmaceutical industries. Currently, most aromatic …
[HTML][HTML] Classification of antimicrobial mechanism of action using dynamic bacterial morphology imaging
X Ouyang, J Hoeksma, RJM Lubbers, TK Siersma… - Scientific Reports, 2022 - nature.com
Antimicrobial resistance is a major threat to human health. Basic knowledge of antimicrobial
mechanism of action (MoA) is imperative for patient care and for identification of novel …
mechanism of action (MoA) is imperative for patient care and for identification of novel …