The extracellular matrix is a complex network of hydrated macromolecular proteins and
sugars that, in concert with bound soluble factors, comprise the acellular stromal …

Cells in tissues experience a plethora of forces that regulate their fate and modulate development
and homeostasis. Cells sense mechanical cues through localized mechanoreceptors …

Mechanical force modulates development, influences tissue homeostasis, and contributes
to disease. Forces sculpt tissue-level behaviors and direct cell fate by engaging …

Early human embryonic development involves extensive lineage diversification, cell-fate
specification and tissue patterning 1 . Despite its basic and clinical importance, early human …

… In this study, Muncie et al. engineered substrates that recapitulate the biophysical properties
of the early embryo and facilitate a ‘‘gastrulationlike’’ morphogenesis of hESCs. They …

Satellite cells (SCs) reside in a dormant state during tissue homeostasis. The specific paracrine
agents and niche cells that maintain SC quiescence remain unknown. We find that Wnt4 …

Using four-dimensional whole-embryo light sheet imaging with improved and accessible
computational tools, we longitudinally reconstruct early murine cardiac development at single-…

Mitochondria control eukaryotic cell fate by producing the energy needed to support life and
the signals required to execute programed cell death. The biochemical milieu is known to …

Differentiation proceeds along a continuum of increasingly fate-restricted intermediates,
referred to as canalization 1 , 2 . Canalization is essential for stabilizing cell fate, but the …

… Srivastava and JM Muncie. V. Srivastava assisted with initial microwell experiments and …
JM Muncie performed AFM experiments and analyzed AFM data. AA Kindberg analyzed all …