Importance The association between red blood cell (RBC) transfusion strategies and health
care–associated infection is not fully understood. Objective To evaluate whether RBC …

Objectives. —To improve end-of-life decision making and reduce the frequency of a mechanically
supported, painful, and prolonged process of dying. Design. —A 2-year prospective …

Telomere shortening is the mechanism underlying replicative aging in fibroblasts. A variety of
reports now claim that inactivation of the p16 INK4a /pRB pathway is required in addition to …

Serine is both a proteinogenic amino acid and the source of one-carbon units essential for
de novo purine and deoxythymidine synthesis. In the canonical pathway of glucose-derived …

Loss of function mutations in Kelch-like ECH Associated Protein 1 (KEAP1), or gain-of-function
mutations in nuclear factor erythroid 2-related factor 2 (NRF2), are common in non-small …

Phosphoenolpyruvate carboxykinase (PEPCK) is well known for its role in gluconeogenesis.
However, PEPCK is also a key regulator of TCA cycle flux. The TCA cycle integrates …

… Rohde contributed to the literature search, table creation, study design and writing; Ms.
Jacobsen contributed to the writing and table creation; and Dr. Rosenberg contributed to the …

Development of efficient sequences for the total syntheses of (±)-actinophyllic acid (rac-1)
and (−)-actinophyllic acid (1) are described. The central step in these syntheses is the aza-…

The first total synthesis of (±)-actinophyllic acid (1) is reported. Key steps of this synthesis
include an intramolecular oxidative coupling of ketone and malonic ester enolates and an aza-…

BACKGROUND Severe sepsis is a common, costly, and complex problem, the epidemiology
of which has only been well studied in the intensive care unit ( ICU ). However, nearly half …