The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy
is associated with increases in genomic instability. Mitotic chromosomal instability — the …

Dynamic regulation of gene expression in response to changing local conditions is critical
for the survival of all organisms. In metazoans, coherent regulation of gene expression …

Inhibition of an initiating oncogene often leads to extensive tumour cell death, a phenomenon
known as oncogene addiction 1 . This has led to the search for compounds that …

Multiple mechanisms have been proposed to explain how Rb and p53 tumor suppressor
loss lead to chromosome instability (CIN). It was recently shown that Rb pathway inhibition …

Hec1 (Highly Expressed in Cancer 1) is one of four proteins of the outer kinetochore Ndc80
complex involved in the dynamic interface between centromeres and spindle microtubules. …

IDH-mutant cancers can develop resistance to isoform-selective IDH inhibition by “isoform
switching” from mutant IDH1 to mutant IDH2 or vice versa, thereby restoring 2HG production …

Oncogenic mutations in isocitrate dehydrogenases 1 and 2 (IDH1/2) produce 2-hydroxyglutarate
(2HG), which inhibits dioxygenases that modulate chromatin dynamics. The effects of …

Oncogenic IDH1/2 mutations produce 2-hydroxyglutarate (2HG), resulting in competitive
inhibition of DNA and protein demethylation. IDH-mutant cancer cells show an inability to …

… Juan Manuel Schvartzman1,* and Andrew M. Intlekofer2,* 1Division of Hematology &
Oncology, Department of Medicine, Columbia University Medical Center, New York, NY …

Intrahepatic cholangiocarcinoma has known histological heterogeneity. Mutations in IDH1 (mIDH1)
define a molecular subclass of intrahepatic cholangiocarcinoma and IDH-targeted …