Epigenetic inheritance is more widespread in plants than in mammals, in part because
mammals erase epigenetic information by germline reprogramming. We sequenced the …

The polarized glandular organization of epithelial cells is frequently lost during development
of carcinoma. However, the specific oncogene targets responsible for polarity disruption …

The opposition between Polycomb repressive complexes (PRCs) and BAF (mSWI/SNF)
complexes has a critical role in both development and disease. Mutations in the genes encoding …

Trithorax-group proteins and their mammalian homologs, including those in BAF (mSWI/SNF)
complexes, are known to oppose the activity of Polycomb repressive complexes (PRCs) 1 , …

Alternative splicing is a powerful mechanism affording extensive proteomic and regulatory
diversity from a limited repertoire of genes. However, the extent to which alternative splicing …

… Calarco, a brilliant scientist, dedicated colleague, and true friend. We thank the Crabtree lab…
Kamakaka and JA Calarco for helpful discussions and E. Miller for sharing curated GEO data …

Recent studies have indicated that nucleosome turnover is rapid, occurring several times
per cell cycle. To access the effect of nucleosome turnover on the epigenetic landscape, we …

In mammals and plants, parental genomic imprinting restricts the expression of specific loci
to one parental allele. Imprinting in mammals relies on sex-dependent de novo deposition of …

Background The male germline in flowering plants differentiates by asymmetric division of
haploid uninucleated microspores, giving rise to a vegetative cell enclosing a smaller …

The resolution and formation of facultative heterochromatin are essential for development,
reprogramming, and oncogenesis. The mechanisms underlying these changes are poorly …