User profiles for J. P. Hazra

Jagadish Prasad Hazra

Postdoctoral assistant
Verified email at physics.ox.ac.uk
Cited by 136

[HTML][HTML] Emergence of slip-ideal-slip behavior in tip-links serve as force filters of sound in hearing

N Arora, JP Hazra, S Roy, GK Bhati, S Gupta… - Nature …, 2024 - nature.com
Tip-links in the inner ear convey force from sound and trigger mechanotransduction. Here,
we present evidence that tip-links (collectively as heterotetrameric complexes of cadherins) …

[HTML][HTML] Anisotropy in mechanical unfolding of protein upon partner-assisted pulling and handle-assisted pulling

N Arora, JP Hazra, S Rakshit - Communications Biology, 2021 - nature.com
Proteins as force-sensors respond to mechanical cues and regulate signaling in physiology.
Proteins commonly connect the source and response points of mechanical cues in two …

Nanoparticle fabrication on bacterial microcompartment surface for the development of hybrid enzyme-inorganic catalyst

NK Bari, G Kumar, A Bhatt, JP Hazra, A Garg… - ACS …, 2018 - ACS Publications
Bacterial microcompartments (MCPs) are polyhedral organelles containing an enzyme cluster
wrapped inside a protein shell and carry out specific enzyme reactions in bacteria. These …

[HTML][HTML] ESCORTing proteins directly from whole cell-lysate for single-molecule studies

S Srinivasan, JP Hazra, GS Singaraju, D Deb… - Analytical …, 2017 - Elsevier
We have developed a method for Enzymatic Sortase-assisted Covalent Orientation-specific
Restraint Tethering (ESCORT) recombinant proteins onto surfaces directly from cell-lysate. …

Broken force dispersal network in tip-links by the mutations at the Ca2+-binding residues induces hearing-loss

JP Hazra, A Sagar, N Arora, D Deb, S Kaur… - Biochemical …, 2019 - portlandpress.com
Tip-link as force-sensor in hearing conveys the mechanical force originating from sound to
ion-channels while maintaining the integrity of the entire sensory assembly in the inner ear. …

[PDF][PDF] Variable mutations at the p53-R273 oncogenic hotspot position leads to altered properties

A Garg, JP Hazra, MK Sannigrahi, S Rakshit, S Sinha - Biophysical journal, 2020 - cell.com
… CD measurements were done in a JASCO 810 spectropolarimeter (Tokyo, Japan). 5 mM
concentration of WTp53 or its variants was placed in a 0.1-cm pathlength quartz cell (Hellma …

Functional protein shells fabricated from the self-assembling protein sheets of prokaryotic organelles

NK Bari, G Kumar, JP Hazra, S Kaur… - Journal of materials …, 2020 - pubs.rsc.org
Fabricating protein compartments from protein units is challenging and limited by the use of
external stimuli and crosslinkers. Here we explore the fabrication of all-protein compartments …

A major shell protein of 1, 2‐propanediol utilization microcompartment conserves the activity of its signature enzyme at higher temperatures

G Kumar, NK Bari, JP Hazra, S Sinha - ChemBioChem, 2022 - Wiley Online Library
A classic example of an all‐protein natural nano‐bioreactor, the bacterial microcompartment
is a prokaryotic organelle that confines enzymes in a small volume enveloped by an outer …

Structural basis of the strong cell‐cell junction formed by cadherin‐23

…, A Sagar, A Kumar, JS Samuel, JP Hazra… - The FEBS …, 2020 - Wiley Online Library
Cadherin‐23, a giant atypical cadherin, form homophilic interactions at the cell–cell junction
of epithelial cells and heterophilic interactions with protocadherin‐15 at the tip links of …

Probe into a multi-protein prokaryotic organelle using thermal scanning assay reveals distinct properties of the core and the shell

NK Bari, JP Hazra, G Kumar, S Kaur, S Sinha - Biochimica et Biophysica …, 2020 - Elsevier
Background Bacterial microcompartments represent the only reported category of prokaryotic
organelles that are capable of functioning as independent bioreactors. In this organelle, a …