User profiles for J. P. Zackular

Joseph P. Zackular

Assistant Professor, University of Pennsylvania and Children's Hospital of Philadelphia
Verified email at email.chop.edu
Cited by 3081

[HTML][HTML] Nutritional immunity: S100 proteins at the host-pathogen interface

JP Zackular, WJ Chazin, EP Skaar - Journal of Biological Chemistry, 2015 - ASBMB
The S100 family of EF-hand calcium (Ca 2+ )-binding proteins is essential for a wide range
of cellular functions. During infection, certain S100 proteins act as damage-associated …

The gut microbiome modulates colon tumorigenesis

JP Zackular, NT Baxter, KD Iverson, WD Sadler… - MBio, 2013 - Am Soc Microbiol
Recent studies have shown that individuals with colorectal cancer have an altered gut
microbiome compared to healthy controls. It remains unclear whether these differences are a …

The human gut microbiome as a screening tool for colorectal cancer

JP Zackular, MAM Rogers, MT Ruffin IV… - Cancer prevention …, 2014 - AACR
Recent studies have suggested that the gut microbiome may be an important factor in the
development of colorectal cancer. Abnormalities in the gut microbiome have been reported in …

[HTML][HTML] Structure of the gut microbiome following colonization with human feces determines colonic tumor burden

NT Baxter, JP Zackular, GY Chen, PD Schloss - Microbiome, 2014 - Springer
Background A growing body of evidence indicates that the gut microbiome plays a role in
the development of colorectal cancer (CRC). Patients with CRC harbor gut microbiomes that …

Enterococci enhance Clostridioides difficile pathogenesis

…, GM Dunny, BM Prentice, EP Skaar, JP Zackular - Nature, 2022 - nature.com
Enteric pathogens are exposed to a dynamic polymicrobial environment in the gastrointestinal
tract 1 . This microbial community has been shown to be important during infection, but …

Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection

JP Zackular, JL Moore, AT Jordan, LJ Juttukonda… - Nature medicine, 2016 - nature.com
Clostridium difficile is the most commonly reported nosocomial pathogen in the United
States and is an urgent public health concern worldwide 1 . Over the past decade, incidence, …

Microbe–microbe interactions during Clostridioides difficile infection

A Abbas, JP Zackular - Current opinion in microbiology, 2020 - Elsevier
Clostridioides difficile is the leading cause of hospital-acquired gastrointestinal infections
and a major public health burden in the United States. C. difficile infection causes a spectrum …

Stabilization of the murine gut microbiome following weaning

PD Schloss, AM Schubert, JP Zackular, KD Iverson… - Gut …, 2012 - Taylor & Francis
Ecologists hypothesize that community structure and stability affect productivity, sensitivity to
invasion and extinction, and resilience and resistance to perturbations. Viewed in the …

Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile)

…, EE Tanner-Smith, JP Zackular… - Cochrane database …, 2023 - cochranelibrary.com
Background Clostridioides difficile (formerly known as Clostridium difficile) is a bacterium
that can cause potentially life‐threatening diarrheal illness in individuals with an unhealthy …

[HTML][HTML] Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori–induced inflammation–driven gastric carcinogenesis

…, BP Cummings, CR Flynn, JP Zackular… - The Journal of …, 2022 - Am Soc Clin Investig
Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host,
and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in …