User profiles for J. P. Zackular
Joseph P. ZackularAssistant Professor, University of Pennsylvania and Children's Hospital of Philadelphia Verified email at email.chop.edu Cited by 3081 |
[HTML][HTML] Nutritional immunity: S100 proteins at the host-pathogen interface
The S100 family of EF-hand calcium (Ca 2+ )-binding proteins is essential for a wide range
of cellular functions. During infection, certain S100 proteins act as damage-associated …
of cellular functions. During infection, certain S100 proteins act as damage-associated …
The gut microbiome modulates colon tumorigenesis
Recent studies have shown that individuals with colorectal cancer have an altered gut
microbiome compared to healthy controls. It remains unclear whether these differences are a …
microbiome compared to healthy controls. It remains unclear whether these differences are a …
The human gut microbiome as a screening tool for colorectal cancer
JP Zackular, MAM Rogers, MT Ruffin IV… - Cancer prevention …, 2014 - AACR
Recent studies have suggested that the gut microbiome may be an important factor in the
development of colorectal cancer. Abnormalities in the gut microbiome have been reported in …
development of colorectal cancer. Abnormalities in the gut microbiome have been reported in …
[HTML][HTML] Structure of the gut microbiome following colonization with human feces determines colonic tumor burden
Background A growing body of evidence indicates that the gut microbiome plays a role in
the development of colorectal cancer (CRC). Patients with CRC harbor gut microbiomes that …
the development of colorectal cancer (CRC). Patients with CRC harbor gut microbiomes that …
Enterococci enhance Clostridioides difficile pathogenesis
Enteric pathogens are exposed to a dynamic polymicrobial environment in the gastrointestinal
tract 1 . This microbial community has been shown to be important during infection, but …
tract 1 . This microbial community has been shown to be important during infection, but …
Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection
JP Zackular, JL Moore, AT Jordan, LJ Juttukonda… - Nature medicine, 2016 - nature.com
Clostridium difficile is the most commonly reported nosocomial pathogen in the United
States and is an urgent public health concern worldwide 1 . Over the past decade, incidence, …
States and is an urgent public health concern worldwide 1 . Over the past decade, incidence, …
Microbe–microbe interactions during Clostridioides difficile infection
A Abbas, JP Zackular - Current opinion in microbiology, 2020 - Elsevier
Clostridioides difficile is the leading cause of hospital-acquired gastrointestinal infections
and a major public health burden in the United States. C. difficile infection causes a spectrum …
and a major public health burden in the United States. C. difficile infection causes a spectrum …
Stabilization of the murine gut microbiome following weaning
Ecologists hypothesize that community structure and stability affect productivity, sensitivity to
invasion and extinction, and resilience and resistance to perturbations. Viewed in the …
invasion and extinction, and resilience and resistance to perturbations. Viewed in the …
Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile)
…, EE Tanner-Smith, JP Zackular… - Cochrane database …, 2023 - cochranelibrary.com
Background Clostridioides difficile (formerly known as Clostridium difficile) is a bacterium
that can cause potentially life‐threatening diarrheal illness in individuals with an unhealthy …
that can cause potentially life‐threatening diarrheal illness in individuals with an unhealthy …
[HTML][HTML] Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori–induced inflammation–driven gastric carcinogenesis
…, BP Cummings, CR Flynn, JP Zackular… - The Journal of …, 2022 - Am Soc Clin Investig
Gastric carcinogenesis is mediated by complex interactions among Helicobacter pylori, host,
and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in …
and environmental factors. Here, we demonstrate that H. pylori augmented gastric injury in …