The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free survival in
HR + /HER2 − breast cancer when combined with anti-hormonals. We sought to discover PAL …

Background The clinical success of immune checkpoint inhibitors demonstrates that
reactivation of the human immune system delivers durable responses for some patients and …

Biomarker development for prediction of patient response to therapy is one of the goals of
molecular profiling of human tissues. Due to the large number of transcripts, relatively limited …

The Gene Ontology (GO) offers a comprehensive and standardized way to describe a
protein's biological role. Proteins are annotated with GO terms based on direct or indirect …

The question of protein homology versus analogy arises when proteins share a common
function or a common structural fold without any statistically significant amino acid sequence …

We present a protein fold‐recognition method that uses a comprehensive statistical interpretation
of structural Hidden Markov Models (HMMs). The structure/fold recognition is done by …

We present a knowledge‐based threading scoring function that exploits the information
about protein structure contained in residue packing/neighbor preferences. The proposed …

A short review of the threading approach to protein structure prediction, including presentation
of some open statistical problems. Also discussed is one of the likely sources of the …

Transposable elements (TEs) are mobile genetic elements in eukaryotic genomes. Recent
research highlights the important role of TEs in the embryogenesis, neurodevelopment, and …

We present a new procedure for optimization of a threading scoring function. A scoring
function is usually formulated in terms of the structural environment states that describe the …