The global burden of disease caused by group A streptococcus (GAS) is not known. We
review recent population-based data to estimate the burden of GAS diseases and highlight …

… in: Martin DR Tagg JR Streptococci and streptococcal diseases: entering the new
millennium. Institute of Environmental Science and Research, Porirua2000: 503-512 …

emm sequence typing is the most widely used method for defining group A streptococcal (GAS)
strains, and has been applied to isolates in all regions of the world. We did a systematic …

Background As mortality rates decline, life expectancy increases, and populations age, non-fatal
outcomes of diseases and injuries are becoming a larger component of the global …

Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together
all available epidemiological data using a coherent measurement framework, standardised …

Background Rheumatic heart disease remains an important preventable cause of
cardiovascular death and disability, particularly in low-income and middle-income countries. We …

Background Remarkable financial and political efforts have been focused on the reduction
of child mortality during the past few decades. Timely measurements of levels and trends in …

Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused
by infection with group A Streptococcus. The long-term damage to cardiac valves caused by …

Background Antibiotics are widely administered to children with the intention of preventing
urinary tract infection, but adequately powered, placebo-controlled trials regarding efficacy …

Related article, page 470 an impressive list of unexpected associations between genes or
chromosomal regions and a broad range of diseases. There have been few, if any, similar …