Sound strategies for hearing restoration
GSG Géléoc, JR Holt - Science, 2014 - science.org
… Inner-ear gene-therapy research in the Holt/Géléoc lab is supported by the Bertarelli
Foundation Program in Translational Neuroscience and Neuroengineering. This review was …
Foundation Program in Translational Neuroscience and Neuroengineering. This review was …
A measurement of the spin asymmetry and determination of the structure function g1 in deep inelastic muon-proton scattering
…, K Hamacher, D Von Harrach, P Hayman, JR Holt… - Physics Letters B, 1988 - Elsevier
The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by
longitudinally polarised protons has been measured over a large x range (0.01<x<0.7). The spin-…
longitudinally polarised protons has been measured over a large x range (0.01<x<0.7). The spin-…
An investigation of the spin structure of the proton in deep inelastic scattering of polarised muons on polarised protons
…, K Hamacher, DV Harrach, PJ Hayman, JR Holt… - Nuclear Physics B, 1989 - Elsevier
The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by
longitudinally polarised protons has been measured in the range 0.01<×<0.7. The spin dependent …
longitudinally polarised protons has been measured in the range 0.01<×<0.7. The spin dependent …
Emerging gene therapies for genetic hearing loss
H Ahmed, O Shubina-Oleinik, JR Holt - … of the Association for Research in …, 2017 - Springer
Gene therapy, or the treatment of human disease using genetic material, for inner ear
dysfunction is coming of age. Recent progress in developing gene therapy treatments for genetic …
dysfunction is coming of age. Recent progress in developing gene therapy treatments for genetic …
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
Mechanical deflection of the sensory hair bundles of receptor cells in the inner ear causes
ion channels located at the tips of the bundle to open, thereby initiating the perception of …
ion channels located at the tips of the bundle to open, thereby initiating the perception of …
Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation
…, K Kurima, B Pan, AJ Griffith, JR Holt - Pflügers Archiv-European …, 2015 - Springer
Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and
recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes …
recessive forms of deafness in humans and mice. TMC1 is one of eight mammalian TMC genes …
[HTML][HTML] Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
Macrophages perform diverse functions within tissues during immune responses to pathogens
and injury, but molecular mechanisms by which physical properties of the tissue regulate …
and injury, but molecular mechanisms by which physical properties of the tissue regulate …
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
Although genetic factors contribute to almost half of all cases of deafness, treatment options
for genetic deafness are limited 1 , 2 , 3 , 4 , 5 . We developed a genome-editing approach to …
for genetic deafness are limited 1 , 2 , 3 , 4 , 5 . We developed a genome-editing approach to …
[HTML][HTML] Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes
Inner ear hair cells convert the mechanical stimuli of sound, gravity, and head movement
into electrical signals. This mechanotransduction process is initiated by opening of cation …
into electrical signals. This mechanotransduction process is initiated by opening of cation …
[PDF][PDF] TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear
Sensory transduction in auditory and vestibular hair cells requires expression of transmembrane
channel-like (Tmc) 1 and 2 genes, but the function of these genes is unknown. To …
channel-like (Tmc) 1 and 2 genes, but the function of these genes is unknown. To …