We present a highly scalable assay for whole-genome methylation profiling of single cells.
We use our approach, single-cell combinatorial indexing for methylation analysis (sci-MET), …

Rett syndrome (RTT) is a debilitating neurological disorder caused by mutations in the gene
encoding the transcription factor Methyl CpG Binding Protein 2 (MECP2). A distinct disorder …

Here we present a comprehensive map of the accessible chromatin landscape of the
mouse hippocampus at single-cell resolution. Substantial advances of this work include the …

Programmable RNA editing is gaining momentum as an approach to repair mutations, but
its efficiency in repairing endogenous mutant RNA in complex tissue is unknown. Here we …

Rett syndrome is a neurological disease due to loss-of-function mutations in the transcription
factor, Methyl CpG binding protein 2 (MECP2). Because overexpression of endogenous …

Localized translation and the requisite trafficking of the mRNA template play significant
roles in the nervous system including the establishment of dendrites and axons, axon path-finding…

The ability to detect RNA molecules in situ has long had important applications for molecular
biological studies. Enzyme or dye-labeled antisense in vitro runoff transcripts and synthetic …

The molecular mechanisms that govern the timing and fate of neural stem-cell differentiation
toward the distinct neural lineages of the nervous system are not well defined. The …

The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …

Background The genetics of depression has been explored in genome-wide association
studies that focused on either major depressive disorder or depressive symptoms with mostly …