The cellular mechanism(s) linking macrophages to norepinephrine (NE)-mediated regulation
of thermogenesis have been a topic of debate. Here we identify sympathetic neuron–…

… Seidman and colleagues address this problem by defining cell- and disease-specific
enhancer landscapes that enable inference of key transcription factors that drive myeloid cell …

Tissue environment plays a powerful role in establishing and maintaining the distinct
phenotypes of resident macrophages, but the underlying molecular mechanisms remain poorly …

The nature of obesity-associated islet inflammation and its impact on β cell abnormalities
remains poorly defined. Here, we explore immune cell components of islet inflammation and …

Diet and exercise form the foundation of a healthy lifestyle. These are especially important
for people living with diabetes mellitus, as they are the most practical non‐pharmacological …

Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and
proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown. Here…

Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol
transport and protects against atherosclerosis in mouse models. Most synthetic LXR agonists …

Innate immune defense against deep tissue infection by Staphylococcus aureus is orchestrated
by fibroblasts that become antimicrobial when triggered to differentiate into adipocytes. …

Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and
affected cell types are incompletely understood. Here, investigation of effects of natural genetic …

Objective Delay discounting (DD) is the choice of a smaller immediate reward over a larger
delayed reward, which has been associated with a number of maladaptive behaviors. …