Near-infrared catecholamine nanosensors for high spatiotemporal dopamine imaging
Dopamine neuromodulation of neural synapses is a process implicated in a number of
critical brain functions and diseases. Development of protocols to visualize this dynamic …
critical brain functions and diseases. Development of protocols to visualize this dynamic …
Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor
Neuromodulation plays a critical role in brain function in both health and disease, and new
tools that capture neuromodulation with high spatial and temporal resolution are needed. …
tools that capture neuromodulation with high spatial and temporal resolution are needed. …
High-throughput evolution of near-infrared serotonin nanosensors
…, D Yang, AG Beyene, JT Del Bonis-O'Donnell… - Science …, 2019 - science.org
Imaging neuromodulation with synthetic probes is an emerging technology for studying
neurotransmission. However, most synthetic probes are developed through conjugation of …
neurotransmission. However, most synthetic probes are developed through conjugation of …
Electrostatic assemblies of single-walled carbon nanotubes and sequence-tunable peptoid polymers detect a lectin protein and its target sugars
A primary limitation to real-time imaging of metabolites and proteins has been the selective
detection of biomolecules that have no naturally occurring or stable molecular recognition …
detection of biomolecules that have no naturally occurring or stable molecular recognition …
Supervised learning model predicts protein adsorption to carbon nanotubes
Engineered nanoparticles are advantageous for biotechnology applications including
biomolecular sensing and delivery. However, testing compatibility and function of …
biomolecular sensing and delivery. However, testing compatibility and function of …
Advances in nanomaterials for brain microscopy
Microscopic imaging of the brain continues to reveal details of its structure, connectivity, and
function. To further improve our understanding of the emergent properties and functions of …
function. To further improve our understanding of the emergent properties and functions of …
DNA-stabilized silver nanoclusters as specific, ratiometric fluorescent dopamine sensors
JT Del Bonis-O'Donnell, A Thakrar… - ACS chemical …, 2017 - ACS Publications
Neurotransmitters are small molecules that orchestrate complex patterns of brain activity.
Unfortunately, there exist few sensors capable of directly detecting individual neurotransmitters. …
Unfortunately, there exist few sensors capable of directly detecting individual neurotransmitters. …
Mitigation of carbon nanotube neurosensor induced transcriptomic and morphological changes in mouse microglia with surface passivation
Single-walled carbon nanotubes (SWCNT) are used in neuroscience for deep-brain imaging,
neuron activity recording, measuring brain morphology, and imaging neuromodulation. …
neuron activity recording, measuring brain morphology, and imaging neuromodulation. …
Giant acceleration of DNA diffusion in an array of entropic barriers
D Kim, C Bowman, JT Del Bonis-O'Donnell… - Physical Review Letters, 2017 - APS
We investigate with experiments and computer simulations the nonequilibrium dynamics of
DNA polymers crossing arrays of entropic barriers in nanofluidic devices in a pressure-driven …
DNA polymers crossing arrays of entropic barriers in nanofluidic devices in a pressure-driven …
A universal design for a DNA probe providing ratiometric fluorescence detection by generation of silver nanoclusters
JT Del Bonis-O'Donnell, D Vong, S Pennathur… - Nanoscale, 2016 - pubs.rsc.org
DNA-stabilized silver nanoclusters (AgNCs), the fluorescence emission of which can rival
that of typical organic fluorophores, have made possible a new class of label-free molecular …
that of typical organic fluorophores, have made possible a new class of label-free molecular …