User profiles for J. T. Dudley

Joel Dudley

Institute Director and Associate Professor, Icahn School of Medicine at Mount Sinai
Verified email at mssm.edu
Cited by 66774

Deep learning for healthcare: review, opportunities and challenges

…, F Wang, S Wang, X Jiang, JT Dudley - Briefings in …, 2018 - academic.oup.com
Gaining knowledge and actionable insights from complex, high-dimensional and heterogeneous
biomedical data remains a key challenge in transforming health care. Various types of …

[HTML][HTML] Deep patient: an unsupervised representation to predict the future of patients from the electronic health records

R Miotto, L Li, BA Kidd, JT Dudley - Scientific reports, 2016 - nature.com
Secondary use of electronic health records (EHRs) promises to advance clinical research
and better inform clinical decision making. Challenges in summarizing and representing …

[HTML][HTML] Personal omics profiling reveals dynamic molecular and medical phenotypes

…, S Balasubramanian, M O'Huallachain, JT Dudley… - Cell, 2012 - cell.com
Personalized medicine is expected to benefit from combining genomic information with regular
monitoring of physiological states by multiple high-throughput methods. Here, we present …

Gene expression elucidates functional impact of polygenic risk for schizophrenia

…, YC Wang, MC Mahajan, JMJ Derry, JT Dudley… - Nature …, 2016 - nature.com
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …

Artificial intelligence in cardiology

…, R Miotto, M Ali, E Ashley, JT Dudley - Journal of the American …, 2018 - jacc.org
Dudley is supported by the following grants from the National Institutes of Health: National
Dudley has received consulting fees or honoraria from Janssen Pharmaceuticals, …

Discovery and preclinical validation of drug indications using compendia of public gene expression data

M Sirota, JT Dudley, J Kim, AP Chiang… - Science translational …, 2011 - science.org
The application of established drug compounds to new therapeutic indications, known as
drug repositioning, offers several advantages over traditional drug development, including …

Clinical assessment incorporating a personal genome

…, MT Wheeler, R Chen, TE Klein, FE Dewey, JT Dudley… - The Lancet, 2010 - thelancet.com
Background The cost of genomic information has fallen steeply, but the clinical translation of
genetic risk estimates remains unclear. We aimed to undertake an integrated analysis of a …

[HTML][HTML] Viral dynamics of SARS-CoV-2 variants in vaccinated and unvaccinated persons

…, D Salgado, T Baker, JT Dudley… - … England Journal of …, 2021 - Mass Medical Soc
Viral Dynamics of SARS-CoV-2 Variants in Vaccinated and Unvaccinated Persons | NEJM
Skip to main content NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn …

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease

JT Dudley, M Sirota, M Shenoy, RK Pai… - Science translational …, 2011 - science.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract for which there are few safe and effective therapeutic options for long-term treatment and …

[PDF][PDF] Multiscale analysis of independent Alzheimer's cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus

…, EE Schadt, ME Ehrlich, S Gandy, JT Dudley - Neuron, 2018 - cell.com
Investigators have long suspected that pathogenic microbes might contribute to the onset
and progression of Alzheimer's disease (AD) although definitive evidence has not been …