Electron cryomicroscopy can yield near-atomic resolution structures of highly ordered
macromolecular complexes. Often however some subunits bind in a flexible manner, have …

Mutations in either polycystin-1 (PC1 or PKD1) or polycystin-2 (PC2, PKD2 or TRPP1) cause
autosomal-dominant polycystic kidney disease (ADPKD) through unknown mechanisms. …

… Huiskonen a b c … with noticeable quasi-symmetry, where the subunits deviate significantly
from their ideal positions (Huiskonen, 2018). For instance, both sindbis virus (Chen et al., 2018…

Negative-strand RNA viruses represent a significant class of important pathogens that
cause substantial morbidity and mortality in human and animal hosts worldwide. A defining …

Hantaviruses (family Bunyaviridae) are rodent-borne emerging viruses that cause a serious,
worldwide threat to human health. Hantavirus diseases include hemorrhagic fever with …

Rift Valley fever virus (RVFV) is a member of the genus Phlebovirus within the family
Bunyaviridae. It is a mosquito-borne zoonotic agent that can cause hemorrhagic fever in humans. …

Measles virus is a highly infectious, enveloped, pleomorphic virus. We combined electron
cryotomography with subvolume averaging and immunosorbent electron microscopy to …

Polycystin-2 (PC2), a calcium-activated cation TRP channel, is involved in diverse Ca 2+
signaling pathways. Malfunctioning Ca 2+ regulation in PC2 causes autosomal-dominant …

Lassa virus is an enveloped, bi-segmented RNA virus and the most prevalent and fatal of all
Old World arenaviruses. Virus entry into the host cell is mediated by a tripartite surface spike …

Membranes in cells have defined distributions of lipids in each leaflet, controlled by lipid
scramblases and flip/floppases. However, for some intracellular membranes such as the …