The appropriate secretion of insulin from pancreatic β-cells is critically important to the
maintenance of energy homeostasis. The β-cells must sense and respond suitably to postprandial …

Glucose-stimulated insulin secretion (GSIS) is central to normal control of metabolic fuel
homeostasis, and its impairment is a key element of β-cell failure in type 2 diabetes. Glucose …

In pancreatic β-cells, glucose metabolism signals insulin secretion by altering the cellular
array of messenger molecules. ATP is particularly important, given its role in regulating cation …

The second messenger cAMP exerts powerful stimulatory effects on Ca 2+ signaling and
insulin secretion in pancreatic β-cells. Previous studies of β-cells focused on protein kinase A (…

Uncoupling protein 2 (UCP2) may act as an important regulator of insulin secretion. In this
study, β-cell function in UCP2-deficient mice was examined after a 45% high-fat diet (HFD) to …

Glucose-stimulated insulin secretion (GSIS) from pancreatic islet β-cells is central to control
of mammalian fuel homeostasis. Glucose metabolism mediates GSIS in part via ATP-…

Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2)
in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell defects …

Study objective Emergency Department (ED) visits decreased significantly in the United
States during the COVID-19 pandemic. A troubling proportion of this decrease was among …

Voltage-dependent (Kv) outward K + currents repolarize β-cell action potentials during a
glucose stimulus to limit Ca 2+ entry and insulin secretion. Dominant-negative "knockout" of Kv2 …

Abstract Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical
outcomes. Through a high-throughput cell-based screen, we identified avocatin B, a lipid …