… James W Rocco, MD James W Rocco … in: Mendelsohn J Gray JW Howley PM Israel MA
Thompson CB The molecular basis of cancer. 4th edn. Content Repository Only, Philadelphia…

Since its discovery as an inhibitor of cyclin-dependent kinases 4 and 6, the tumor suppressor
p16 has continued to gain widespread importance in cancer. The high frequency of …

Oropharyngeal squamous cell carcinoma caused by high-risk types of human papillomavirus
(HPV) is now a well-recognized tumor entity whose incidence is on the rise. Most HPV-…

The diverse malignant, stromal, and immune cells in tumors affect growth, metastasis, and
response to therapy. We profiled transcriptomes of ∼6,000 single cells from 18 head and …

Treatment is complex for patients with head and neck (H&N) cancers with specific site of
disease, stage, and pathologic findings guiding treatment decision-making. Treatment planning …

The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity
(including mucosal lip), pharynx, larynx, and paranasal sinuses. Occult primary cancer, …

We demonstrate that ΔNp63α is an essential survival factor in head and neck squamous cell
carcinoma (HNSCC) through its ability to suppress p73-dependent apoptosis. Inhibition of …

Context Human papillomavirus (HPV) is a major cause of oropharyngeal squamous cell
carcinomas, and HPV (and/or surrogate marker p16) status has emerged as a prognostic …

Genomic instability is a hallmark of human cancers, including the 5% caused by human
papillomavirus (HPV). Here we report a striking association between HPV integration and …

OBJECTIVES: Differences among cancer cells within a tumor are important in tumorigenesis
and treatment resistance, yet no measure of intratumor heterogeneity is suitable for routine …