Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human
aging and disease. Thus far, it has proven difficult to develop successful treatment strategies …

Detection of Gram-negative bacterial lipid A by the extracellular sensor, myeloid differentiation
2 (MD2)/Toll-like receptor 4 (TLR4), or the intracellular inflammasome sensors, CASP4 …

Background Monogenic gain-of-function protein aggregation diseases, including Huntington’s
disease, exhibit substantial variability in age of onset, penetrance, and clinical symptoms, …

Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging
endoplasmic reticulum (ER) proteostasis. Anticipatory activation of the unfolded protein …

The inflammasome is essential for host defense against intracellular bacterial pathogens,
including Legionella pneumophila, the causative agent of the severe pneumonia Legionnaires…

Background Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit
clinical variation in the age of onset and progression, driven in part by inter-individual genetic …

Study Design. A cross-sectional observational design study was conducted to determine
lumbar repositioning error in 15 subjects who had chronic low back pain with a clinical …

A full description with illustrations is given of each of 385 rain forest tree species. Keys and
the principal characteristics used for identification are based on ever-present botanical …

An inventory of the rain forest (200 000 ha) in New South Wales in 2 (hardback) volumes. The
first volume has 8 chapters and introduces and defines the rain forests and their subforms, …

In an essay entitled “Variations on Negations and the Heresy of Black Feminist Creativity,”
Black feminist Michele Wallace explores the difficulties of producing and presenting a “black …