Hepatocyte nuclear factor 4-alpha (HNF4-α) is a nuclear receptor regulating metabolism,
cell junctions, differentiation and proliferation in liver and intestinal epithelial cells. Mutations …

Background Hnf4α, an epithelial specific transcriptional regulator, is decreased in inflammatory
bowel disease and protects against chemically-induced colitis in mice. However, the …

Hepatocyte nuclear factor 4α (HNF4α) is a regulator of hepatocyte and pancreatic transcription.
Hnf4α deletion in the mouse is embryonically lethal with severe defects in visceral …

Hepatocyte nuclear factor-4α (Hnf4α) is a transcription factor that controls epithelial cell polarity
and morphogenesis. Hnf4α conditional deletion during postnatal development has minor …

HNF4α is a nuclear receptor produced as 12 isoforms from two promoters by alternative
splicing. To characterize the transcriptional capacities of all 12 HNF4α isoforms, stable lines …

Colorectal tumors are immersed in an array of tumor-promoting factors including extracellular
nucleotides such as uridine 5′‑diphosphate (UDP). UDP is the endogenous agonist of …

HNF4α is a key nuclear receptor for regulating gene expression in the gut. Although both P1
and P2 isoform classes of HNF4α are expressed in colonic epithelium, specific inhibition of …

The elevated expression of the splicing regulator SRSF10 in metastatic colorectal cancer (CRC)
stimulates the production of the pro-tumorigenic BCLAF1-L splice variant. We …

Normal cellular models able to efficiently recapitulate intestinal epithelial cell differentiation
in culture are not yet available. The aim of this work was to establish and genetically …

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that acts as a master regulator
of genes for several endoderm-derived tissues, including the intestine, in which it plays a …