[PDF][PDF] Beyond GWASs: illuminating the dark road from association to function
Genome-wide association studies (GWASs) have enabled the discovery of common genetic
variation contributing to normal and pathological traits and clinical drug responses, but …
variation contributing to normal and pathological traits and clinical drug responses, but …
Genome-wide association study identifies novel breast cancer susceptibility loci
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
[HTML][HTML] GFDL's CM2 global coupled climate models. Part I: Formulation and simulation characteristics
The formulation and simulation characteristics of two new global coupled climate models
developed at NOAA's Geophysical Fluid Dynamics Laboratory (GFDL) are described. The …
developed at NOAA's Geophysical Fluid Dynamics Laboratory (GFDL) are described. The …
Association analysis identifies 65 new breast cancer risk loci
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …
A common coding variant in CASP8 is associated with breast cancer risk
…, J Beesley, A Mannermaa, J Hartikainen… - Nature …, 2007 - nature.com
The Breast Cancer Association Consortium (BCAC) has been established to conduct combined
case-control analyses with augmented statistical power to try to confirm putative genetic …
case-control analyses with augmented statistical power to try to confirm putative genetic …
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Genome-wide association studies (GWAS) and large-scale replication studies have identified
common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial …
common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial …
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 …
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 …
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23. 2
…, Australian Ovarian Cancer Study Group, J Beesley… - Nature …, 2009 - nature.com
Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility
loci, but these explain only a small fraction of the familial risk of the disease. Five of these …
loci, but these explain only a small fraction of the familial risk of the disease. Five of these …
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
The de novo design of α-helical peptides for supramolecular self-assembly
JL Beesley, DN Woolfson - Current opinion in biotechnology, 2019 - Elsevier
… Author links open overlay panel Joseph L Beesley 1 , Derek N Woolfson 1 2 3 … J Am
Chem Soc, 135 (2013), pp. 5161-5166 … J Am Chem Soc, 131 (2008), pp. 928-930 …
Chem Soc, 135 (2013), pp. 5161-5166 … J Am Chem Soc, 131 (2008), pp. 928-930 …