Background: Although dexamethasone is routinely delivered intratympanically for hearing
loss, we know little of its inner ear pharmacokinetics. Dexamethasone 21-phosphate is the …

The standard treatment for many hearing disorders is glucocorticoid therapy, although the
cochlear mechanisms involved in steroid-responsive hearing loss are poorly understood. …

Hypothesis Although the glucocorticoid prednisone is the standard therapy for autoimmune
sensorineural hearing loss, what this hormone does in the ear to restore hearing is not known…

Disabling hearing loss impacts ∼466 million individuals worldwide with 34 million children
affected. Gene and pharmacotherapeutic strategies to rescue auditory function in mouse …

Objectives/Hypothesis: The inner ear is at risk for sensorineural hearing loss in both acute
and chronic otitis media (OM), but the mechanisms underlying sensorineural hearing loss are …

• Vancomycin has been reported to be an ototoxic drug in the clinical literature. At best, this
literature is confusing. There are no reports of ototoxicity of vancomycin in experimental …

Recently this laboratory showed aldosterone, a mineralocorticoid that only enhances sodium
transport, was as effective as the glucocorticoid prednisolone in restoring cochlear function …

Therapeutic strategies to restore hearing and balance in mouse models of inner ear disease
aim to rescue sensory function by gene replacement, augmentation, knock down or knock …

Objectives/Hypothesis: Chronic otitis media is a significant clinical problem. Understanding
the mechanisms of chronic otitis media is critical for its control. However, little is known of …

A recent advancement in enzyme-linked immunosorbent assay (ELISA) technology is the
multiplex antibody array that measures multiple proteins simultaneously within a single sample…