Multiple signatures of somatic mutations have been identified in cancer genomes. Exome
sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common …

Purpose: Despite intense research, treatment options for patients with mesothelioma are
limited and offer only modest survival advantage. We screened a large panel of compounds in …

Drug resistance is an almost inevitable consequence of cancer therapy and ultimately proves
fatal for the majority of patients. In many cases, this is the consequence of specific gene …

… j if there is a gene g i belonging to G such that g i is a member of P and f(g i , s j ) = 1, ie at least
one gene in the pathway P is altered in the j… in sample s j , we introduce the variable X j = |…

Drug resistance is ultimately the cause of death for most cancer patients – even initially
strong responses to treatment are usually followed by the emergence of resistance over time. …

Induction therapy for acute myeloid leukaemia (AML) has changed with the approval of a
number of new agents. Clinical guidelines can struggle to keep pace with an evolving …

BRAF V600E mutations occur in a subset of colon cancers. These are typically resistant to
chemotherapy and are associated with a poor outcome. Combination treatment with BRAF …

10-20% of lung adenocarcinoma patients harbour activating mutations in EGFR. Although
treatment with the EGFR kinase inhibitor osimertinib has improved overall survival in such …

Extracting functional information from sequencing data is a main question of computational
cancer genomics. We present a computational pipeline to characterize how cancers from …

… j if there is a gene g i belonging to G such that g i is a member of P and f(g i ,s j ) = 1, ie at least
one gene in the pathway P is altered in the j… in sample s j , we introduce the variable X j = |{…