During the past several years, there has been a renewed interest in the mechanisms by which
lead poisoning disrupts brain function. In part, this is related to clinical observations that …

▪ Abstract Epigenetics is comprised of the stable and heritable (or potentially heritable)
changes in gene expression that do not entail a change in DNA sequence. The role of …

… Joseph Bressler an overview on the molecular basis of neurologic disorders in lead …
Belloni-Olivi, L., Annadata, M., Goldstein, GW, and Bressler, JP 1996. Phosphorylation of membrane …

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic
age”,“DNAm age”, have been shown to be robust biomarkers of age in humans. We …

Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…

General cognitive function is substantially heritable across the human life course from
adolescence to old age. We investigated the genetic contribution to variation in this important, …

Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …

Background Chronic low-grade inflammation reflects a subclinical immune response
implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …