Abstract Evaluation of TMB as a predictive biomarker creates the need to harmonize panel-based
TMB estimation and standardize its reporting. TMB can improve the predictive …

In 2014, we described a method to quantify percentage of tumor-infiltrating lymphocytes (TILs)
on hematoxylin and eosin-stained slides of breast cancer samples using light microscopy …

Increased proliferation is a hallmark of malignant tumors. The proliferation marker Ki67 has
been investigated as a breast cancer biomarker, but despite 32 years of research the best …

Background Tumour-infiltrating lymphocytes (TILs) are predictive for response to neoadjuvant
chemotherapy in triple-negative breast cancer (TNBC) and HER2-positive breast cancer, …

Validating prognostic or predictive candidate genes in appropriately powered breast cancer
cohorts are of utmost interest. Our aim was to develop an online tool to draw survival plots, …

Purpose Preclinical data suggest a contribution of the immune system to chemotherapy
response. In this study, we investigated the prespecified hypothesis that the presence of a …

In the last decade, optimized treatment for non-small cell lung cancer had lead to improved
prognosis, but the overall survival is still very short. To further understand the molecular basis …

Gene or protein expression data are usually represented by metric or at least ordinal
variables. In order to translate a continuous variable into a clinical decision, it is necessary to …

Purpose Our aim was to analyze and validate the prognostic impact of the novel
International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/…

Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of
many cancers. However, the precise molecular composition of lipids in tumors remains …