Data-intensive research depends on tools that manage multidimensional, heterogeneous
datasets. We built OME Remote Objects (OMERO), a software platform that enables access to …

Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease of the
human motor system. In this Seminar, we summarise current concepts about the origin of the …

Data sharing is important in the biological sciences to prevent duplication of effort, to promote
scientific integrity, and to facilitate and disseminate scientific discovery. Sharing requires …

The pairing of massive data sets with processes—or algorithms—written in computer code to
sort through, organize, extract, or mine them has made inroads in almost every major social …

The Open Microscopy Environment (OME) defines a data model and a software implementation
to serve as an informatics framework for imaging in biological microscopy experiments, …

The expression of CD45RA is generally associated with naive T cells. However, a subset of
effector memory T cells re-expresses CD45RA (termed TEMRA) after antigenic stimulation …

The rapid pace of innovation in biological imaging and the diversity of its applications have
prevented the establishment of a community-agreed standardized data format. We propose …

A growing community is constructing a next-generation file format (NGFF) for bioimaging to
overcome problems of scalability and heterogeneity. Organized by the Open Microscopy …

This article considers the issue of opacity as a problem for socially consequential mechanisms
of classification and ranking, such as spam filters, credit card fraud detection, search …

The development of immunoregulatory networks is important to prevent disease. However,
these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we …