Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

Background Genome-wide association studies (GWAS) in Parkinson's disease have increased
the scope of biological knowledge about the disease over the past decade. We aimed to …

The authors recently demonstrated that genetic triplication of the SNCA locus causes Parkinson
disease. Here it is shown that SNCA triplication results in a doubling in the amount of α-…

Amyloid deposits, neurofibrillary tangles, and neuronal cell death in selectively vulnerable
brain regions are the chief hallmarks in Alzheimer's (AD) brains. Glycogen synthase kinase-3 (…

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability. …

Central Asia is a vast region at the crossroads of different habitats, cultures, and trade routes.
Little is known about the genetics and the history of the population of this region. We …

Background Alzheimer's disease and its complications are the leading cause of death in
adults with Down syndrome. Studies have assessed Alzheimer's disease in individuals with …

Mutations in three genes (PSEN1, PSEN2, and APP) have been identified in patients with
early-onset (<65years) Alzheimer's disease (AD). We performed a screening for mutations in …

Background Dementia with Lewy bodies is the second most common form of dementia in
elderly people but has been overshadowed in the research field, partly because of similarities …

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed
whole-genome sequencing in large cohorts of LBD cases and neurologically healthy …