Remarkable gains have been made in global health in the past 25 years, but progress has
not been uniform. Mortality and morbidity from common conditions needing surgery have …

Antibiotics have always been considered one of the wonder discoveries of the 20th century.
This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities, …

… phenotypic array studies (HH Wang and J. Davies, unpublished observations). Bacteria
carrying … & Davies, J. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to …

Using a combination of iterative structure-based design and an analysis of oral pharmacokinetics
and antiviral activity, AG1343 (Viracept, nelfinavir mesylate), a nonpeptidic inhibitor of …

The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS
CoV-2 and named for its close genetic similarity to SARS CoV-1 that caused severe acute …

The crystal structure of the ribonuclease (RNase) H domain of HIV-1 reverse transcriptase (RT)
has been determined at a resolution of 2.4 Å and refined to a crystallographic R factor of …

We have searched the human genome for genes that predispose to type 1 (insulin-dependent)
diabetes mellitus using semi-automated fluorescence-based technology and linkage …

Using positional cloning strategies, we have identified a CTG triplet repeat that undergoes
expansion in myotonic dystrophy patients. This sequence is highly variable in the normal …

Test-Retest: In the original study, patients with LBP were tested twice at a 24-hour interval (n=
22, r= 0.99). If the test retest interval is extended to 4 days, the correlation of scores …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes of …