Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other
tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we use …

Fructose consumption has been growing exponentially and, concomitant with this, the increase
in the incidence of obesity and associated complications has followed the same behavior…

Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …

In recent decades, metabolic syndrome has become a public health problem throughout the
world. Longitudinal studies in humans have several limitations due to the invasive nature of …

Epidemiological studies indicate continuous increases in the prevalence of Alzheimer’s
Disease (AD) in the next few decades. The key feature of this disease is hippocampal …

Lowering carbohydrate consumption effectively lowers glucose, but impacts on inflammation
are unclear. The objectives of this study were to: 1) determine whether reducing …

The main purpose of this research was to investigate the alterations in the aerobic capacity
and appearance of metabolic alterations in Wistar rats fed on fructose-rich diet. We separated …

It is well documented that exhaustive physical exercise leads to inflammation and skeletal
muscle tissue damage. With this in mind, melatonin has been acutely administered before …

Newborn rats (6 days old) received alloxan intraperitoneally (A= 250 mg/kg bw). Rats injected
with vehicle (citrate buffer) were used as controls (C). After weaning, half of the animals …

The present study evaluated the effects of exercise training on pyruvate carboxylase protein
(PCB) levels in hepatic tissue and glucose homeostasis control in obese mice. Swiss mice …