User profiles for J. Duebel
Jens DuebelVision Institute Paris Verified email at inserm.fr Cited by 4585 |
[HTML][HTML] Partial recovery of visual function in a blind patient after optogenetic therapy
…, C de Montleau, E Gutman, I Audo, J Duebel… - Nature medicine, 2021 - nature.com
Optogenetics may enable mutation-independent, circuit-specific restoration of neuronal
function in neurological diseases. Retinitis pigmentosa is a neurodegenerative eye disease …
function in neurological diseases. Retinitis pigmentosa is a neurodegenerative eye disease …
Optogenetics
… Doroudchi MM, Greenberg KP, Liu J, et al. Virally delivered channelrhodopsin-2 safely
and effectively restores visual function in multiple mouse models of blindness. Mol Ther …
and effectively restores visual function in multiple mouse models of blindness. Mol Ther …
Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
Retinitis pigmentosa refers to a diverse group of hereditary diseases that lead to incurable
blindness, affecting two million people worldwide. As a common pathology, rod …
blindness, affecting two million people worldwide. As a common pathology, rod …
[HTML][HTML] Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs
Adaptation to different levels of illumination is central to the function of the retina. Here, we
demonstrate that levels of the miR-183/96/182 cluster, miR-204, and miR-211 are regulated …
demonstrate that levels of the miR-183/96/182 cluster, miR-204, and miR-211 are regulated …
The primordial, blue-cone color system of the mouse retina
Humans and old world primates have trichromatic color vision based on three spectral types
of cone [long-wavelength (L-), middle-wavelength (M-), and short-wavelength (S-) cones]. …
of cone [long-wavelength (L-), middle-wavelength (M-), and short-wavelength (S-) cones]. …
A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo
… the waveform triggered on the electrodes by cell j. Times ti … aij and bij are the amplitude
factors for spike time ti for the template j, … Choose the i; j ð Þ pair with the highest scalar product, …
factors for spike time ti for the template j, … Choose the i; j ð Þ pair with the highest scalar product, …
Generation of storable retinal organoids and retinal pigmented epithelium from adherent human iPS cells in xeno-free and feeder-free conditions
…, A Potey, M Belle, O Rabesandratana, J Duebel… - Stem …, 2017 - academic.oup.com
Human induced pluripotent stem cells (hiPSCs) are potentially useful in regenerative
therapies for retinal disease. For medical applications, therapeutic retinal cells, such as retinal …
therapies for retinal disease. For medical applications, therapeutic retinal cells, such as retinal …
[HTML][HTML] Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV restores ON and OFF visual responses in blind mice
Most inherited retinal dystrophies display progressive photoreceptor cell degeneration
leading to severe visual impairment. Optogenetic reactivation of retinal neurons mediated by …
leading to severe visual impairment. Optogenetic reactivation of retinal neurons mediated by …
[HTML][HTML] Functional Fluorescent Ca2+ Indicator Proteins in Transgenic Mice under TET Control
… Maximum intensity projection of two-photon 3D stacks taken from a brain slice (J) and a …
does the accumulation of mobile (see Figure 3J), cytosolic, and responsive FCIP begin. The …
does the accumulation of mobile (see Figure 3J), cytosolic, and responsive FCIP begin. The …
Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina
Targeting the photosensitive ion channel channelrhodopsin‐2 (ChR2) to the retinal circuitry
downstream of photoreceptors holds promise in treating vision loss caused by retinal …
downstream of photoreceptors holds promise in treating vision loss caused by retinal …