User profiles for J. Duebel

Jens Duebel

Vision Institute Paris
Verified email at inserm.fr
Cited by 4585

[HTML][HTML] Partial recovery of visual function in a blind patient after optogenetic therapy

…, C de Montleau, E Gutman, I Audo, J Duebel… - Nature medicine, 2021 - nature.com
Optogenetics may enable mutation-independent, circuit-specific restoration of neuronal
function in neurological diseases. Retinitis pigmentosa is a neurodegenerative eye disease …

Optogenetics

J Duebel, K Marazova, JA Sahel - Current opinion in …, 2015 - journals.lww.com
… Doroudchi MM, Greenberg KP, Liu J, et al. Virally delivered channelrhodopsin-2 safely
and effectively restores visual function in multiple mouse models of blindness. Mol Ther …

Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa

V Busskamp, J Duebel, D Balya, M Fradot, TJ Viney… - science, 2010 - science.org
Retinitis pigmentosa refers to a diverse group of hereditary diseases that lead to incurable
blindness, affecting two million people worldwide. As a common pathology, rod …

[HTML][HTML] Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs

…, I Markiewicz, MB Stadler, S Ribi, J Richter, J Duebel… - Cell, 2010 - cell.com
Adaptation to different levels of illumination is central to the function of the retina. Here, we
demonstrate that levels of the miR-183/96/182 cluster, miR-204, and miR-211 are regulated …

The primordial, blue-cone color system of the mouse retina

S Haverkamp, H Wässle, J Duebel, T Kuner… - Journal of …, 2005 - Soc Neuroscience
Humans and old world primates have trichromatic color vision based on three spectral types
of cone [long-wavelength (L-), middle-wavelength (M-), and short-wavelength (S-) cones]. …

A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

…, M Stimberg, F Jetter, G Zeck, S Picaud, J Duebel… - Elife, 2018 - elifesciences.org
… the waveform triggered on the electrodes by cell j. Times ti … aij and bij are the amplitude
factors for spike time ti for the template j, … Choose the i; j ð Þ pair with the highest scalar product, …

Generation of storable retinal organoids and retinal pigmented epithelium from adherent human iPS cells in xeno-free and feeder-free conditions

…, A Potey, M Belle, O Rabesandratana, J Duebel… - Stem …, 2017 - academic.oup.com
Human induced pluripotent stem cells (hiPSCs) are potentially useful in regenerative
therapies for retinal disease. For medical applications, therapeutic retinal cells, such as retinal …

[HTML][HTML] Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV restores ON and OFF visual responses in blind mice

…, E Bamberg, JA Sahel, S Picaud, J Duebel… - Molecular Therapy, 2015 - cell.com
Most inherited retinal dystrophies display progressive photoreceptor cell degeneration
leading to severe visual impairment. Optogenetic reactivation of retinal neurons mediated by …

[HTML][HTML] Functional Fluorescent Ca2+ Indicator Proteins in Transgenic Mice under TET Control

…, ME Larkum, G Giese, M Both, J Duebel, J Waters… - PLoS …, 2004 - journals.plos.org
… Maximum intensity projection of two-photon 3D stacks taken from a brain slice (J) and a …
does the accumulation of mobile (see Figure 3J), cytosolic, and responsive FCIP begin. The …

Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina

…, JA Sahel, S Picaud, D Dalkara, J Duebel - EMBO molecular …, 2016 - embopress.org
Targeting the photosensitive ion channel channelrhodopsin‐2 (ChR2) to the retinal circuitry
downstream of photoreceptors holds promise in treating vision loss caused by retinal …