Molecular mechanisms underlying sarcopenia, the age-related loss of skeletal muscle mass
and function, remain unclear. To identify molecular changes that correlated best with …

A group of genes that are highly and specifically expressed in proliferating skeletal myoblasts
during myogenesis was identified. Expression of one of these genes, Hmga2, increases …

Insulin-like growth factor 1 (IGF1) induces skeletal muscle hypertrophy by activating the
IGF1R/IRS1/PI3K/Akt pathway. However the effect of IGF1 in differentiated muscle is limited by …

There is a lack of pharmacological interventions available for sarcopenia, a progressive age-associated
loss of muscle mass, leading to a decline in mobility and quality of life. We found …

Declines in skeletal muscle size and strength, often seen with chronic wasting diseases,
prolonged or high-dose glucocorticoid therapy, and the natural aging process in mammals, are …

Autophagy is a vesicular trafficking pathway that regulates the degradation of aggregated
proteins and damaged organelles. Initiation of autophagy requires several multiprotein …

The metallothionein-human growth hormone fusion gene (MThGH), constructed by fusing the
mouse metallothionein promoter with the human growth hormone gene, was microinjected …

The effects of increased dietary protein on resistance training (RT)-induced changes in body
composition and skeletal muscle fiber size are uncertain in older people. Objectives We …

Progressive loss of muscle mass and function due to muscle fiber atrophy and loss in the
elderly and chronically ill is now defined as sarcopenia. It is a major contributor to loss of …

Neutrophils are a major component of the innate immune response. Their homeostasis is
maintained, in part, by the regulated release of neutrophils from the bone marrow. Constitutive …