Extension of neurites from a cell body is essential to form a functional nervous system; however,
the mechanisms underlying neuritogenesis are poorly understood. Ena/VASP proteins …

Mammalian cortical development involves neuronal migration and neuritogenesis; this latter
process forms the structural precursors to axons and dendrites. Elucidating the pathways …

Oestrogen receptor alpha (ERα) signalling in the ventromedial hypothalamus (VMH) contributes
to energy homeostasis by modulating physical activity and thermogenesis. However, …

Homeotherms maintain a stable internal body temperature despite changing environments.
During energy deficiency, some species can cease to defend their body temperature and …

… JE van Veen performed spine explant and peptide array overlay experiments. RE … JE van
Veen made the initial observation of Slit-induced filopodium elongation. RE McConnell and FB …

Adjuvant tamoxifen therapy improves survival in breast cancer patients. Unfortunately, long-term
treatment comes with side effects that impact health and quality of life, including hot …

Recent studies in Caenorhabditis elegans show that crossover interference, which usually
limits the number of exchanges per meiotic bivalent to just ‘one', requires the continuity of …

Loss of RBMS3 cooperates with BRAF V600E to induce lung tumorigenesis, providing a
deeper understanding of the molecular mechanisms underlying mutant BRAF-driven lung …

10.7554/eLife.43668.001 Human lung adenocarcinoma exhibits a propensity for de-differentiation,
complicating diagnosis and treatment, and predicting poorer patient survival. In …

Liver X receptors limit cellular lipid uptake by stimulating the transcription of inducible
degrader of the low-density lipoprotein receptor (IDOL), an E3 ubiquitin ligase that targets …