Gene flow between phenotypically divergent populations can disrupt local adaptation or,
alternatively, may stimulate adaptive evolution by increasing genetic variation. We capitalised …

Chemiluminescent iridium‐based sensors which demonstrate oxygen dependent responses
have been developed. The molecular probes, named IrCL‐1, IrCL‐2 and IrCL‐3 consist of …

Azanone (HNO) is a reactive nitrogen species with pronounced biological activity and high
therapeutic potential for cardiovascular dysfunction. A critical barrier to understanding the …

Purpose: AP5346 is designed to target a diaminocyclohexane platinum (Pt) moiety to tumors
through pH-sensitive linkage to a 25 kDa hydroxypropylmethacrylamide polymer. The goal …

Genetic rescue, an increase in population growth owing to the infusion of new alleles, can
aid the persistence of small populations. Its use as a management tool is limited by a lack of …

Symmetrical protein oligomers are ubiquitous in biological systems and perform key structural
and regulatory functions. However, there are few methods for constructing such oligomers. …

Multiresonance perfluorocarbon emulsions (Oxypherol and Fluosol-DA) were imaged in
tumor-bearing mice using 19 F spin-echo magnetic resonance imaging in vivo. Multiple thin-…

Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI) techniques were evaluated as
potential non-invasive predictive biomarkers of radiation response. Semi quantitative blood-…

Regulation of physiological pH is integral for proper whole body and cellular function, and
disruptions in pH homeostasis can be both a cause and effect of disease. In light of this, many …

Oxygenation and tissue hypoxia play critical roles in mammalian biology and contribute to
aggressive phenotypes in cancerous tumors, driving research to develop accurate and easy-to…