Mammalian genomes encode genetic information in their linear sequence, but appropriate
expression of their genes requires chromosomes to fold into complex three-dimensional …

… We next sought to investigate the extent to which CTCF disruption affects higher-order
segregation of active and inactive chromosome domains into A and B compartments (Gibcus and …

We describe a method, Hi–C, to comprehensively detect chromatin interactions in the
mammalian nucleus. This method is based on Chromosome Conformation Capture, in which …

INTRODUCTION During mitosis, cells compact their chromosomes into dense rod-shaped
structures to ensure their reliable transmission to daughter cells. Our work explores how cells …

Over the past decade, 3C-related methods have provided remarkable insights into chromosome
folding in vivo. To overcome the limited resolution of prior studies, we extend a recently …

Chromosome conformation capture-based methods such as Hi-C have become mainstream
techniques for the study of the 3D organization of genomes. These methods convert …

Platinum-based chemotherapies such as cisplatin are used as first-line treatment for many
cancers. Although there is often a high initial responsiveness, the majority of patients …

Chromosome conformation capture (3C) assays are used to map chromatin interactions
genome-wide. Chromatin interaction maps provide insights into the spatial organization of …

Hodgkin lymphoma (HL) is derived from preapoptotic germinal center B cells, although a
general loss of B cell phenotype is noted. Using quantitative reverse transcription-polymerase …

MicroRNA (miRNA) sponges are transcripts with repeated miRNA antisense sequences that
can sequester miRNAs from endogenous targets. MiRNA sponges are valuable tools for …