The vital roles of thyroid hormone in multiple aspects of perinatal brain development have
been known for over a century. In the last decades, the molecular mechanisms underlying …

Studies in humans and in animal models show negative correlations between thyroid
hormone (TH) levels and longevity. TH signaling is implicated in maintaining and integrating …

Males and females responses to gestational overnutrition set the stage for subsequent sex-specific
differences in adult onset non communicable diseases. Placenta, as a widely …

Thyroid hormone (TH) signalling, an evolutionary conserved pathway, is crucial for brain
function and cognition throughout life, from early development to ageing. In humans, TH …

10.7554/eLife.29996.001 In the adult brain, both neurons and oligodendrocytes can be
generated from neural stem cells located within the Sub-Ventricular Zone (SVZ). Physiological …

… Author links open overlay panel JD Gothié , A. Sébillot , C. Luongo , M. … J.-DG received
PhD grants from région Île-de-France DIM Cerveau&Pensée and fondation pour la recherche …

Choroid plexus epithelial cells produce and secrete transthyretin (TTR). TTR binds and
distributes thyroid hormone (TH) to brain cells via the cerebrospinal fluid. The adult murine …

… (j) Representative western blot of SNPH protein in cell homogenates of oligodendrocytes
as they mature in vitro. The histograms present quantification of western blot immunoreactive …

In the vertebrate brain, neural stem cells (NSCs) generate both neuronal and glial cells
throughout life. However, their neuro‐ and gliogenic capacity changes as a function of the …

Mitochondria are dynamic organelles that produce energy and molecular precursors that
are essential for myelin synthesis. Unlike in neurons, mitochondria in oligodendrocytes …