Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Cytokines provide cells with the ability to communicate with one another and orchestrate
complex multicellular behaviour. There is an emerging understanding of the role that cytokines …

Calciphylaxis is a rare but devastating condition that has continued to challenge the medical
community since its early descriptions in the scientific literature many decades ago. It is …

We constructed a transgenic mouse model that mimics the human autoimmune disease
multiple sclerosis in its spontaneous induction and pathology. Transgenic mice were …

Multiple sclerosis is an inflammatory, demyelinating disease of the central nervous system (CNS)
characterized by a wide range of clinical signs 1 . The location of lesions in the CNS is …

… 3 J) and white matter of the brain stem, midbrain, and cerebral cortex was also observed.
Focal … J). Astrogliosis was occasionally noted in tissues surrounding affected vessels (Fig. 3 L) …

Encounters with antigen can stimulate T cells to become activated and proliferate, become
nonresponsive to antigen, or to die. T cell death was shown to be a physiological response to …

This protocol details a method to actively induce experimental allergic encephalomyelitis (EAE),
a widely used animal model for studies of multiple sclerosis. EAE is induced by …

Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system,
and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory …

… Depending on the nature of the question under investigation, it may be of interest to use
atypical EAE models (see Stromnes and Goverman for examples of strain/peptide combinations …