Cerebral organoids—3D cultures of human cerebral tissue derived from pluripotent stem
cells—have emerged as models of human cortical development. However, the extent to which …

The human brain has undergone substantial change since humans diverged from chimpanzees
and the other great apes 1 , 2 . However, the genetic and developmental programs that …

The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas,
aims to create a comprehensive reference map of cells during development. This will be …

Conventional two-dimensional differentiation from pluripotency fails to recapitulate cell
interactions occurring during organogenesis. Three-dimensional organoids generate complex …

Self-organizing three-dimensional cellular models derived from human pluripotent stem
cells or primary tissue have great potential to provide insights into how the human nervous …

Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Direct lineage reprogramming represents a remarkable conversion of cellular and
transcriptome states 1 , 2 , 3 . However, the intermediate stages through which individual cells …

Intestinal Th17 cells are induced and accumulate in response to colonization with a
subgroup of intestinal microbes such as segmented filamentous bacteria (SFB) and certain …

The cumulative activity of all of the body’s cells, with their myriad interactions, life histories,
and environmental experiences, gives rise to a condition that is distinctly human and specific …

The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …