The enteric nervous system (ENS) is derived from both the vagal and sacral component of
the neural crest (NC). Here, we present the derivation of sacral ENS precursors from human …

Defects in neural crest development have been implicated in many human disorders, but
information about human neural crest formation mostly depends on extrapolation from model …

10.7554/eLife.35786.001 The neural crest (NC) is a multipotent embryonic cell population that
generates distinct cell types in an axial position-dependent manner. The production of NC …

The neural crest is a transient embryonic tissue that gives rise to a multitude of derivatives in
an axially restricted manner. An in vitro counterpart to neural crest can be derived from …

WNT/β-catenin signaling is crucial for neural crest (NC) formation, yet the effects of the
magnitude of the WNT signal remain ill-defined. Using a robust model of human NC formation …

Human embryonic stem cells (hESCs) display substantial heterogeneity in gene expression,
implying the existence of discrete substates within the stem cell compartment. To determine …

The enteric nervous system (ENS) is derived primarily from the vagal neural crest, a migratory
multipotent cell population emerging from the dorsal neural tube between somites 1 and 7. …

The neural crest is a transient embryonic tissue that originates from the border of the neural
plate prior to delamination and migration throughout the developing embryo, where it …

In the 20 years since the first human pluripotent stem cell (hPSC) lines were established,
there have been a plethora of protocols developed that allow us to generate a wide range of …

… J. The CMV CP gene was cloned into pGA643 resulting in pGCMS. (8) A 264-bp fragment
of pTAG1, which carries the TNV CP gene in pSK, was deleted by cutting with EcoRI (made …