Inflammasomes are multiprotein complexes that function as sensors of endogenous or
exogenous damage-associated molecular patterns. Here, we show that deficiency of NLRP6 in …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome
and the leading cause of chronic liver disease in the Western world. Twenty per cent of …

Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial
protective mechanism at the interface between the eukaryotic and prokaryotic cells of the …

RNA, including long noncoding RNA (lncRNA), is known to be an abundant and important
structural component of the nuclear matrix. However, the molecular identities, functional roles …

Inflammasomes are a group of protein complexes built around several proteins, including
NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and …

Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health
challenge. The pathophysiology is unknown, and no effective treatments have been found to …

Nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins are a family
of innate immune receptors that play a pivotal role in microbial sensing, leading to the …

Mental health profoundly impacts inflammatory responses in the body. This is particularly
apparent in inflammatory bowel disease (IBD), in which psychological stress is associated with …

Acute exposure to ionizing radiation induces massive cell death and severe damage to tissues
containing actively proliferating cells, including bone marrow and the gastrointestinal tract…

Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no
effective medical therapies yet exist. CCMs arise from the loss of an adaptor complex that …