User profiles for J. Hench
James L. HenchAssociate Professor, Duke University Verified email at duke.edu Cited by 3253 |
Invited review: Prion‐like transmission and spreading of tau pathology
F Clavaguera, J Hench, M Goedert… - Neuropathology and …, 2015 - Wiley Online Library
… Alternatively tau aggregates may first be transported anterogradely towards the synaptic
terminal (I) where tau aggregates might be released by exocytosis (J) and subsequently are …
terminal (I) where tau aggregates might be released by exocytosis (J) and subsequently are …
DNA methylation-based classification of central nervous system tumours
…, R Bjerkvig, J Cryan, M Farrell, M Deckert, J Hench… - Nature, 2018 - nature.com
Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system, standardization …
For the approximately 100 known tumour types of the central nervous system, standardization …
Hunting coronavirus by transmission electron microscopy–a guide to SARS‐CoV‐2‐associated ultrastructural pathology in COVID‐19 tissues
…, MC Herzig, R Gosert, T Menter, J Hench… - …, 2021 - Wiley Online Library
Transmission electron microscopy has become a valuable tool to investigate tissues of
COVID‐19 patients because it allows visualisation of SARS‐CoV‐2, but the ‘virus‐like particles’ …
COVID‐19 patients because it allows visualisation of SARS‐CoV‐2, but the ‘virus‐like particles’ …
[HTML][HTML] Liquid biopsy in clinical management of breast, lung, and colorectal cancer
IB Hench, J Hench, M Tolnay - Frontiers in medicine, 2018 - frontiersin.org
Examination of tumor molecular characteristics by liquid biopsy is likely to greatly influence
personalized cancer patient management. Analysis of circulating tumor DNA (ctDNA), …
personalized cancer patient management. Analysis of circulating tumor DNA (ctDNA), …
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes
Parkinson’s disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy …
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are Lewy …
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
…, RA Crowther, S Frank, J Hench… - Proceedings of the …, 2013 - National Acad Sciences
Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous
human neurodegenerative diseases, including Alzheimer’s disease, tangle-only dementia, Pick …
human neurodegenerative diseases, including Alzheimer’s disease, tangle-only dementia, Pick …
[HTML][HTML] Sarcoma classification by DNA methylation profiling
…, C Hartmann, O Staszewski, M Prinz, J Hench… - Nature …, 2021 - nature.com
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some entities …
children. They represent a morphologically heterogeneous class of tumours and some entities …
[PDF][PDF] Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
C. elegans insulin-like signaling regulates metabolism, development, and life span. This
signaling pathway negatively regulates the activity of the forkhead transcription factor DAF-16. …
signaling pathway negatively regulates the activity of the forkhead transcription factor DAF-16. …
[HTML][HTML] High frequency temperature variability reduces the risk of coral bleaching
…, G Pawlak, DJ Barshis, JL Hench… - Nature …, 2018 - nature.com
Coral bleaching is the detrimental expulsion of algal symbionts from their cnidarian hosts,
and predominantly occurs when corals are exposed to thermal stress. The incidence and …
and predominantly occurs when corals are exposed to thermal stress. The incidence and …
Integrated molecular-morphologic meningioma classification: a multicenter retrospective analysis, retrospectively and prospectively validated
…, KD Aldape, S Brandner, J Hench… - Journal of clinical …, 2021 - ascopubs.org
PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …