User profiles for J. K. Ichida
 | Justin IchidaUniversity of Southern California Verified email at usc.edu Cited by 6716 |
[PDF][PDF] A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog
The combined activity of three transcription factors can reprogram adult cells into induced
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …
[PDF][PDF] Conversion of mouse and human fibroblasts into functional spinal motor neurons
The mammalian nervous system comprises many distinct neuronal subtypes, each with its
own phenotype and differential sensitivity to degenerative disease. Although specific …
own phenotype and differential sensitivity to degenerative disease. Although specific …
[PDF][PDF] Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death
Expanded GGGGCC (G4C2) nucleotide repeats within the C9ORF72 gene are the most
common genetic mutation associated with both amyotrophic lateral sclerosis (ALS) and …
common genetic mutation associated with both amyotrophic lateral sclerosis (ALS) and …
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic …
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
…, M Maeda, T Maeda, T Sugawara, JK Ichida… - Nature …, 2015 - nature.com
PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that
reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid-…
reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid-…
Probing disorders of the nervous system using reprogramming approaches
JK Ichida, E Kiskinis - The EMBO journal, 2015 - embopress.org
The groundbreaking technologies of induced pluripotency and lineage conversion have
generated a genuine opportunity to address fundamental aspects of the diseases that affect the …
generated a genuine opportunity to address fundamental aspects of the diseases that affect the …
CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity
Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of
amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). The nucleotide-…
amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). The nucleotide-…
Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts
Reprogramming somatic cells from one cell fate to another can generate specific neurons
suitable for disease modeling. To maximize the utility of patient-derived neurons, they must …
suitable for disease modeling. To maximize the utility of patient-derived neurons, they must …
[PDF][PDF] ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
Frontotemporal dementia (FTD) because of MAPT mutation causes pathological accumulation
of tau and glutamatergic cortical neuronal death by unknown mechanisms. We used …
of tau and glutamatergic cortical neuronal death by unknown mechanisms. We used …
[PDF][PDF] p53 is a central regulator driving neurodegeneration caused by C9orf72 poly (PR)
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a …
dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a …