User profiles for J. Kankanala
 | jayakanth kankanala1cBio, Inc Verified email at 1cbio.com Cited by 1114 |
Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1, 3-diones: dual inhibition against HIV …
…, KA Kirby, DJ Wilson, J Kankanala… - Journal of medicinal …, 2015 - ACS Publications
Reverse transcriptase (RT) associated ribonuclease H (RNase H) remains the only virally
encoded enzymatic function not targeted by current chemotherapy against human …
encoded enzymatic function not targeted by current chemotherapy against human …
5′-Silylated 3′-1, 2, 3-triazolyl thymidine analogues as inhibitors of West Nile virus and dengue virus
…, L Qiu, J Zhang, J Kankanala… - Journal of medicinal …, 2015 - ACS Publications
West Nile virus (WNV) and Dengue virus (DENV) are important human pathogens for which
there are presently no vaccine or specific antivirals. We report herein a 5′-silylated …
there are presently no vaccine or specific antivirals. We report herein a 5′-silylated …
Design, synthesis, and biological evaluations of hydroxypyridonecarboxylic acids as inhibitors of HIV reverse transcriptase associated RNase H
J Kankanala, KA Kirby, F Liu, L Miller… - Journal of medicinal …, 2016 - ACS Publications
Targeting the clinically unvalidated reverse transcriptase (RT) associated ribonuclease H (RNase
H) for human immunodeficiency virus (HIV) drug discovery generally entails …
H) for human immunodeficiency virus (HIV) drug discovery generally entails …
Isoquinoline-1, 3-diones as selective inhibitors of tyrosyl DNA phosphodiesterase II (TDP2)
J Kankanala, C Marchand, M Abdelmalak… - Journal of medicinal …, 2016 - ACS Publications
Tyrosyl DNA phosphodiesterase II (TDP2) is a recently discovered enzyme that specifically
repairs DNA damages induced by topoisomerase II (Top2) poisons and causes resistance to …
repairs DNA damages induced by topoisomerase II (Top2) poisons and causes resistance to …
[PDF][PDF] Structure‐guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release
…, GS Thompson, AP Kalverda, J Kankanala… - …, 2014 - Wiley Online Library
Current interferon‐based therapy for hepatitis C virus (HCV) infection is inadequate,
prompting a shift toward combinations of direct‐acting antivirals (DAA) with the first protease‐…
prompting a shift toward combinations of direct‐acting antivirals (DAA) with the first protease‐…
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2, 4-diones as inhibitors of HIV reverse transcriptase-associated RNase H
Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H
(RNase H) is the only HIV enzymatic function not targeted by current antiviral drugs. …
(RNase H) is the only HIV enzymatic function not targeted by current antiviral drugs. …
3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H
…, MC Casey, J Ji, J Kankanala, J Xie… - Journal of medicinal …, 2016 - ACS Publications
Resistance selection by human immunodeficiency virus (HIV) toward known drug regimens
necessitates the discovery of structurally novel antivirals with a distinct resistance profile. On …
necessitates the discovery of structurally novel antivirals with a distinct resistance profile. On …
Double-winged 3-hydroxypyrimidine-2, 4-diones: potent and selective inhibition against HIV-1 RNase H with significant antiviral activity
…, N Myshakina, DJ Wilson, J Kankanala… - Journal of medicinal …, 2017 - ACS Publications
Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H
(RNase H) remains the only virally encoded enzymatic function yet to be exploited as an …
(RNase H) remains the only virally encoded enzymatic function yet to be exploited as an …
6-Arylthio-3-hydroxypyrimidine-2, 4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity
…, KA Kirby, DJ Wilson, J Kankanala, J Xie… - European journal of …, 2018 - Elsevier
Human immunodeficiency virus (HIV) reverse transcriptase (RT) associated ribonuclease H
(RNase H) remains the only virally encoded enzymatic function not targeted by current drugs…
(RNase H) remains the only virally encoded enzymatic function not targeted by current drugs…
6-Biphenylmethyl-3-hydroxypyrimidine-2, 4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H
…, MC Casey, KA Kirby, DJ Wilson, J Kankanala… - European journal of …, 2018 - Elsevier
Human immunodeficiency virus (HIV) reverse transcriptase (RT)-associated ribonuclease H
(RNase H) remains an unvalidated drug target. Reported HIV RNase H inhibitors generally …
(RNase H) remains an unvalidated drug target. Reported HIV RNase H inhibitors generally …