User profiles for J. Kjems

Jørgen Kjems

- Verified email at mb.au.dk - Cited by 43863

JK Kjems

- Verified email at klitrosebugten.dk - Cited by 7659

The biogenesis, biology and characterization of circular RNAs

…, KK Ebbesen, TB Hansen, J Kjems - Nature reviews …, 2019 - nature.com
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …

The emerging roles of circRNAs in cancer and oncology

…, T Jakobsen, H Hager, J Kjems - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

[HTML][HTML] Circular RNAs in cancer: opportunities and challenges in the field

LS Kristensen, TB Hansen, MT Venø, J Kjems - Oncogene, 2018 - nature.com
Circular RNA (circRNA) is a novel member of the noncoding cancer genome with distinct
properties and diverse cellular functions, which is being explored at a steadily increasing pace. …

Natural RNA circles function as efficient microRNA sponges

…, JB Bramsen, B Finsen, CK Damgaard, J Kjems - Nature, 2013 - nature.com
… Two papers, from the laboratories of Nikolaus Rajewsky and Jørgen Kjems, have now
defined a function for one circRNA that binds the microRNA miR-7. They find that this circRNA is …

Self-assembly of a nanoscale DNA box with a controllable lid

…, V Birkedal, F Besenbacher, KV Gothelf, J Kjems - Nature, 2009 - nature.com
The unique structural motifs and self-recognition properties of DNA can be exploited to generate
self-assembling DNA nanostructures of specific shapes using a ‘bottom-up’ approach 1 …

miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA

…, SB Villadsen, AL Statham, SJ Clark, J Kjems - The EMBO …, 2011 - embopress.org
MicroRNAs (miRNAs) are ∼22 nt non‐coding RNAs that typically bind to the 3′ UTR of target
mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. …

Circular RNA and miR-7 in cancer

TB Hansen, J Kjems, CK Damgaard - Cancer research, 2013 - AACR
MicroRNAs (miRNA) play important roles in fine-tuning gene expression and are often
deregulated in cancer. The identification of competing endogenous RNA and circular RNA (…

[HTML][HTML] RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system

…, A Schmitz, JR Nyengaard, F Besenbacher, J Kjems - Molecular Therapy, 2006 - cell.com
This work introduces a novel chitosan-based siRNA nanoparticle delivery system for RNA
interference in vitro and in vivo. The formation of interpolyelectrolyte complexes between …

Magnetic excitations and ordering in the heavy-electron superconductor

C Broholm, JK Kjems, WJL Buyers, P Matthews… - Physical Review Letters, 1987 - APS
… along the a direction suggests that they occur within a single J … configuration on the U sites,
and that the J=4 multiplet is split into five singlets … We have enjoyed fruitful discussions with J. …

Single-molecule chemical reactions on DNA origami

…, R Subramani, W Mamdouh, J Kjems… - Nature …, 2010 - nature.com
… 3j) show that a large fraction of the DNA origami remains immobilized on the surface after
successive reaction and washing steps (Fig. 3i). However, a slightly higher frequency of dark …