Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life and …

School‐based obesity prevention programs: an evidence‐based review

JA Kropski, PH Keckley, GL Jensen - Obesity, 2008 - Wiley Online Library
Objective: This review seeks to examine the effectiveness of school‐based programs for
reducing childhood overweight or obesity. Methods and Procedures: A systematic review of the …

Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

JC Hewlett, JA Kropski, TS Blackwell - Matrix Biology, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …

[PDF][PDF] SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues

…, PL Lin, CD Bingle, SB Snapper, JA Kropski… - Cell, 2020 - cell.com
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…

[HTML][HTML] An integrated cell atlas of the lung in health and disease

…, P Barbry, TE Duong, CS Falk, KB Meyer, JA Kropski… - Nature Medicine, 2023 - nature.com
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

…, R Walia, TS Blackwell, NE Banovich, JA Kropski - Science …, 2020 - science.org
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic epithelial
remodeling and accumulation of extracellular matrix (ECM). To comprehensively define …

Integrated single-cell atlas of endothelial cells of the human lung

…, MC Nawijn, SA Teichmann, NE Banovich, JA Kropski… - Circulation, 2021 - Am Heart Assoc
Background: Cellular diversity of the lung endothelium has not been systematically
characterized in humans. We provide a reference atlas of human lung endothelial cells (ECs) to …

[PDF][PDF] Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19

…, P Horvath, JA Kropski, R Lafyatis, J Lundeberg… - Immunity, 2020 - cell.com
Temporal resolution of cellular features associated with a severe COVID-19 disease
trajectory is needed for understanding skewed immune responses and defining predictors of …

Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

…, H Katsura, RF Lee, J Ou, NE Banovich, JA Kropski… - Nature cell …, 2020 - nature.com
Stem cells undergo dynamic changes in response to injury to regenerate lost cells. However,
the identity of transitional states and the mechanisms that drive their trajectories remain …

PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

LJ Celada, JA Kropski, JD Herazo-Maya… - Science translational …, 2018 - science.org
Pulmonary fibrosis is a progressive inflammatory disease with high mortality and limited
therapeutic options. Previous genetic and immunologic investigations suggest common …