Idiopathic pulmonary fibrosis: Disease mechanisms and drug development
P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life and …
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life and …
School‐based obesity prevention programs: an evidence‐based review
JA Kropski, PH Keckley, GL Jensen - Obesity, 2008 - Wiley Online Library
Objective: This review seeks to examine the effectiveness of school‐based programs for
reducing childhood overweight or obesity. Methods and Procedures: A systematic review of the …
reducing childhood overweight or obesity. Methods and Procedures: A systematic review of the …
Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets
JC Hewlett, JA Kropski, TS Blackwell - Matrix Biology, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …
[PDF][PDF] SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…
[HTML][HTML] An integrated cell atlas of the lung in health and disease
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …
typically capture only a limited number of donors and disagree on cell type definitions. …
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic epithelial
remodeling and accumulation of extracellular matrix (ECM). To comprehensively define …
remodeling and accumulation of extracellular matrix (ECM). To comprehensively define …
Integrated single-cell atlas of endothelial cells of the human lung
Background: Cellular diversity of the lung endothelium has not been systematically
characterized in humans. We provide a reference atlas of human lung endothelial cells (ECs) to …
characterized in humans. We provide a reference atlas of human lung endothelial cells (ECs) to …
[PDF][PDF] Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19
…, P Horvath, JA Kropski, R Lafyatis, J Lundeberg… - Immunity, 2020 - cell.com
Temporal resolution of cellular features associated with a severe COVID-19 disease
trajectory is needed for understanding skewed immune responses and defining predictors of …
trajectory is needed for understanding skewed immune responses and defining predictors of …
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis
Stem cells undergo dynamic changes in response to injury to regenerate lost cells. However,
the identity of transitional states and the mechanisms that drive their trajectories remain …
the identity of transitional states and the mechanisms that drive their trajectories remain …
PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production
LJ Celada, JA Kropski, JD Herazo-Maya… - Science translational …, 2018 - science.org
Pulmonary fibrosis is a progressive inflammatory disease with high mortality and limited
therapeutic options. Previous genetic and immunologic investigations suggest common …
therapeutic options. Previous genetic and immunologic investigations suggest common …