Genome-wide association studies (GWAS) have reproducibly associated variants within
introns of FTO with increased risk for obesity and type 2 diabetes (T2D) 1 , 2 , 3 . Although the …

… This study is dedicated to the memory of our friend and colleague, José Luis Gómez-Skarmeta.
Chinese muntjac cells were kindly provided by WR Brinkley. Skin fibroblasts of Indian …

In Drosophila imaginal wing discs, the achaete–scute (ac–sc) proneural genes and rhomboid
(veinlet) are expressed in highly resolved patterns that prefigure the positions of sensory …

… and their essentially identical patterns of expression (Gómez-Skarmeta et al., 1996) suggest
… sharing of common enhancers within the Iro-C (Gómez-Skarmeta et al., 1996). As mirr also …

The generation of distinctive cell types that form different tissues and organs requires
precise, temporal and spatial control of gene expression. This depends on specific cis-regulatory …

Vertebrates have greatly elaborated the basic chordate body plan and evolved highly
distinctive genomes that have been sculpted by two whole-genome duplications. Here we …

The genomic regulatory programmes that underlie human organogenesis are poorly
understood. Pancreas development, in particular, has pivotal implications for pancreatic …

Little is known about the molecular mechanisms responsible for axis establishment during
non-embryonic processes such as regeneration and homeostasis. To address this issue, we …

Recent studies of the genome architecture of vertebrates have uncovered two unforeseen
aspects of its organization. First, large regions of the genome, called gene deserts, are devoid …

The identification and characterization of the regulatory activity of genomic sequences is
crucial for understanding how the information contained in genomes is translated into cellular …