Hemoglobin (Hb) is an essential component of the circulatory system of vertebrates. Its chief
physiological function is to transport oxygen from the lungs to the tissues. For reviews of the …

Many important proteins perform their physiological functions under allosteric control, whereby
the binding of a ligand at a specific site influences the binding affinity at a different site. …

NMR spectroscopy and X-ray crystallography, the two primary experimental methods for protein
structure determination at high resolution, have different advantages and disadvantages …

Pirh2 (p53-induced RING-H2 domain protein; also known as Rchy1) is an E3 ubiquitin ligase
involved in a negative-feedback loop with p53. Using NMR spectroscopy, we show that …

Astrocytes react to brain injury with a generic response known as reactive gliosis, which
involves activation of multiple intracellular pathways including several that may be beneficial for …

Importance The administration of a high fraction of oxygen following return of spontaneous
circulation in out-of-hospital cardiac arrest may increase reperfusion brain injury. Objective To …

Importance Type 2 diabetes (T2D) is the leading cause of kidney disease in the US. It is not
known whether glucose-lowering medications differentially affect kidney function. Objective …

Förster resonance energy transfer (FRET) imaging methods provide unique insight into
the spatial distribution of energy transfer and (bio)molecular interaction events, though they …

Background and Aims We conducted a systematic review and meta-analysis to summarize
emerging data on the safety and effectiveness of dual biologic therapy in combination or with …

… (I,J) Rat microglial cultures were exposed to 500 ng/ml HMGB-1 for 18 h and the percentage
of amoeboid microglia (I) or TREM-2 immunostained microgliocytes (J) were evaluated. …