Acute head-fixed recordings in awake mice with multiple Neuropixels probes

S Durand, GR Heller, TK Ramirez, JA Luviano… - Nature …, 2023 - nature.com
Multi-electrode arrays such as Neuropixels probes enable electrophysiological recordings
from large populations of single neurons with high temporal resolution. By using such probes, …

Survey of spiking in the mouse visual system reveals functional hierarchy

…, N Graddis, G Heller, TK Ramirez, H Choi, JA Luviano… - Nature, 2021 - nature.com
The anatomy of the mammalian visual system, from the retina to the neocortex, is organized
hierarchically 1 . However, direct observation of cellular-level functional interactions across …

Hierarchical organization of cortical and thalamic connectivity

…, L Kuan, X Kuang, J Lecoq, P Lesnar, Y Li, J Luviano… - Nature, 2019 - nature.com
… which maps a type of connection cluster (\({C}_{{T}_{i,j}}\in \{1,\ldots ,9\}\), where \({C}_{{T}_{i,j}}\)denotes
the layer termination pattern of the connection from area j to area i for Cre line T…

A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex

…, F Long, J Luviano, K Mace, T Nguyen, J Perkins… - Nature …, 2020 - nature.com
To understand how the brain processes sensory information to guide behavior, we must know
how stimulus representations are transformed throughout the visual cortex. Here we report …

Lenvatinib plus pembrolizumab versus lenvatinib plus placebo for advanced hepatocellular carcinoma (LEAP-002): a randomised, double-blind, phase 3 trial

…, DM Kuba, MS Gonzalez, JC Luviano… - The Lancet …, 2023 - thelancet.com
Background Systemic therapies have improved the management of hepatocellular carcinoma,
but there is still a need to further enhance overall survival in first-line advanced stages. …

VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli

…, S Caldejon, I Kato, JD Larkin, EK Lee, J Luviano… - Elife, 2020 - elifesciences.org
Vasoactive intestinal peptide-expressing (VIP) interneurons in the cortex regulate feedback
inhibition of pyramidal neurons through suppression of somatostatin-expressing (SST) …

A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas

…, N Graddis, G Heller, TK Ramirez, H Choi, JA Luviano… - Biorxiv, 2019 - biorxiv.org
The mammalian visual system, from retina to neocortex, has been extensively studied at
both anatomical and functional levels. Anatomy indicates the cortico-thalamic system is …

Mouse color and wavelength-specific luminance contrast sensitivity are non-uniform across visual space

DJ Denman, JA Luviano, DR Ollerenshaw, S Cross… - Elife, 2018 - elifesciences.org
10.7554/eLife.31209.001 Mammalian visual behaviors, as well as responses in the neural
systems underlying these behaviors, are driven by luminance and color contrast. With …

A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex

…, R Howard, L Kuan, S Lambert, EK Lee, J Luviano… - Nature …, 2023 - nature.com
Identification of structural connections between neurons is a prerequisite to understanding
brain function. Here we developed a pipeline to systematically map brain-wide monosynaptic …

The organization of intracortical connections by layer and cell class in the mouse brain

…, A Henry, A Ho, R Howard, L Kuan, J Lecoq, J Luviano… - BioRxiv, 2018 - biorxiv.org
The mammalian cortex is a laminar structure composed of many cell types densely interconnected
in complex ways. Recent systematic efforts to map the mouse mesoscale connectome …