While reducing the burden of brain disorders remains a top priority of organizations like the
World Health Organization and National Institutes of Health, the development of novel, safe …

We compare the evidence from human neuroimaging studies for and against two of the major
hypotheses of how alterations in the brain's reward system underlie addiction. One of these…

Over the last quarter century, researchers have peered into the living human brain to develop
and refine mechanistic accounts of alcohol-induced behavior, as well as neurobiological …

People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink
in social settings, yet the effect of alcohol on human brain circuits involved in reward and …

Marijuana is the most commonly used illicit drug in the United States, but little is known
about its effects on the human brain, particularly on reward/aversion regions implicated in …

Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental
illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic risk …

… Gilman and group obtained had more to do with the mechanisms of the study, such as the …
Author Contributions: Drs Gilman and Potter had full access to all of the data in the study and …

Alcohol is often used to modulate mood states. Alcohol drinkers report that they use alcohol
both to enhance positive affect and to reduce dysphoria, and alcohol‐dependent patients …

Heavy alcohol consumption during young adulthood is a risk factor for the development of
serious alcohol use disorders. Research has shown that individual differences in subjective …

Alcohol is thought to contribute to an increase in risk‐taking behavior, but the neural
correlates underlying this effect are not well understood. In this study, participants were given …